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Co-Existence of Phenylketonuria Either With Maple Syrup Urine Disease or Sandhoff Disease in Two Patients From Iran: Emphasizing the Role of Consanguinity Publisher Pubmed



Abiri M1, 2 ; Talebi S1 ; Uitto J3 ; Youssefian L1, 3 ; Vahidnezhad H1, 2, 3 ; Shirzad T4 ; Salehpour S5 ; Zeinali S2, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, United States
  4. 4. Medical Genetics Laboratory, Kawsar Human Genetics Research Center, Tehran, Iran
  5. 5. Department of Pediatric Endocrinology and Metabolism, Mofid Children Hospital, Genomic Research Center, Shahid Beheshti Medical University, No. 68, Golfam St., Jordan Ave., Tehran, Iran

Source: Journal of Pediatric Endocrinology and Metabolism Published:2016


Abstract

Most inborn errors of metabolism (IEMs) are inherited in an autosomal recessive manner. IEMs are one of the major concerns in Iran due to its extensive consanguineous marriages. Herein, we report two patients with two co-existent IEMs: a girl affected by classic phenylketonuria (PKU) and maple syrup urine disease (MSUD) and a male patient affected with Sandhoff disease and PKU, where Sandhoff disease was suspected due to the presence of a cherry-red spot in the eyes at 6 months which is unrelated to PKU. Sequencing of candidate genes in the first patient revealed one novel and three recurrent compound heterozygous mutations of p.Ser231Pro and p.Ala300Ser in the PAH gene and p.Glu330Lys and p.Arg170Cys mutations in the BCKDHB gene. Genetic testing results in the second patient showed previously reported homozygous mutations of p.Arg261Gln in the PAH and p.Arg533Cys mutation in the HEXB gene. Genetic testing confirmed the clinical diagnosis of both diseases in both patients. To the best of our knowledge; this is the first report of the co-existence of two distinct genetic disorders in two individuals from Iran. Co-existent different IEMs in patients complicated the clinical diagnosis and management of the diseases. © 2016 Walter de Gruyter GmbH, Berlin/Boston.
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