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Effect of Breast Cancer Surgery on Levels of Depression and Anxiety: A Systematic Review and Meta-Analysis Publisher Pubmed



Movahed F1 ; Dehbozorgi M2 ; Goodarzi S3, 4 ; Abianeh FE1 ; Bahri RA1 ; Shafiee A4
Authors

Source: BMC Cancer Published:2025


Abstract

Background: Breast cancer surgery is a critical intervention with potentially significant psychological impacts. This systematic review and meta-analysis investigate the effect of different surgical approaches on levels of depression and anxiety in breast cancer patients. Methods: Following the PRISMA 2020 guidelines, we conducted a comprehensive search of international bibliometric databases including PubMed, Scopus, Web of Science, and Embase, up to March 21, 2024. Results: From 1576 identified articles, 13 studies were included after screening and eligibility assessments. Meta-analysis results indicated a significant reduction in depression (SMD: -0.14; 95% CI: -0.25 to -0.02) and anxiety (SMD: -0.42; 95% CI: -0.56 to -0.28) following breast cancer surgery. Subgroup analysis revealed that mastectomy patients experienced a notable decrease in both depression and anxiety, while results for breast-conserving surgery and reconstruction were more varied. Conclusions: Breast cancer surgery is associated with a decrease in depression and anxiety, particularly following mastectomy. Further research should focus on long-term psychological effects and the development of tailored interventions for different surgical types. © The Author(s) 2025.
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