Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Successful Treatment of Isotretinoin Induced Musculoskeletal Pain by Vitamin B12 and Folic Acid Publisher



Feily A1
Authors

Source: Open Access Macedonian Journal of Medical Sciences Published:2019


Abstract

BACKGROUND: Daily supplementation with vitamin B12 and folate, which are the cofactors of the enzymatic reactions involved in Hcy metabolism, can lower plasma levels of Hcy and prevent osteoporosis induced by retinoid CASE PRESENTATION: We reported six patients with nodulocystic acne who reported musculoskeletal pain after taking isotretinoin which successfully treated with daily supplementation of folic acid and B12. CONCLUSION: We suggest our colleagues consider these supplements when a patient suffers from musculoskeletal pain following starting isotretinoin and continue the treatment as well. In the end, the authors concluded that robust trials with more patients are needed to establish the efficacy of Vit B12 and folic acid in the treatment of isotretinoin induced musculoskeletal pain. © 2019 Amir Feily.
Related Docs
View other Related Docs
1. Efficacy of Folic Acid and Vitamin B12 Replacement Therapies in the Reduction of Adverse Effects of Isotretinoin: A Randomized Controlled Trial, Skinmed (2018)
2. The Effect of Low-Dose Isotretinoin Therapy on Serum Androgen Levels in Women With Acne Vulgaris, International Journal of Women's Dermatology (2020)
3. Effect of Vitamin E Supplementation on Plasma and Urine Levels of Isoprostane F2α in Randomized Controlled Clinical Trials: A Systematic Review and Meta-Analysis, International Journal for Vitamin and Nutrition Research (2017)
Experts (# of related papers)
View all Related Experts
Robabeh Abedini (2)
Sakineh Shab-Bidar (2)
Other Related Docs
4. A Comprehensive Review and Meta-Regression Analysis of Randomized Controlled Trials Examining the Impact of Vitamin B12 Supplementation on Homocysteine Levels, Nutrition Reviews (2024)
5. Vitamin C Supplementation Lowers Advanced Glycation End Products (Ages) and Malondialdehyde (Mda) in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Food Science and Nutrition (2023)
6. Vitamin D (Foki) Receptor Gene Polymorphism Is Associated With Vitamin D Deficiency and Chronic Musculoskeletal Pain. a Meta-Analysis, International Journal for Vitamin and Nutrition Research (2017)
7. Determining Functional Vitamin B12 Deficiency in the Elderly, Iranian Red Crescent Medical Journal (2015)
8. Serum Levels of Folic Acid and Vitamin B12 in Basal Cell Carcinoma Patients: A Case-Control Study, Iranian Journal of Dermatology (2021)
9. The Effect of Folic Acid Supplementation on Body Weight and Body Mass Index: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2023)
10. The Effect of Vitamin D on Nonspecific Low Back Pain, International Journal of Rheumatic Diseases (2015)
11. The Effects of Folic Acid Supplementation on Pro-Inflammatory Mediators: A Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials, Clinical Therapeutics (2021)
12. Effect of Vitamin E Supplementation on Serum C-Reactive Protein Level: A Meta-Analysis of Randomized Controlled Trials, European Journal of Clinical Nutrition (2015)
13. Effects of Vitamin D Supplementation in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis, Heliyon (2025)
14. Serum Levels of Vitamin B12, Folic Acid, and Homocysteine in Patients With Vitiligo, Iranian Journal of Dermatology (2015)
15. Influence of Vitamin a Supplementation on Inflammatory Biomarkers in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Scientific Reports (2022)
16. Effects of Vibration Therapy and Vitamin D Supplement on Eccentric Exercise-Induced Delayed Onset Muscle Soreness in Female Students, Comparative Exercise Physiology (2020)
17. The Effect of Vitamin C on Oxidative Stress Indices and Skin Regimentation of Vitiligo Patients, Archives of Dermatological Research (2023)
18. Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Nutrients (2021)