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Hospitalization, Major Complications and Mortality in Acute Myocardial Infarction Patients During the Covid-19 Era: A Systematic Review and Meta-Analysis Publisher



Pourasghari H1 ; Tavolinejad H2, 3 ; Soleimanpour S4 ; Abdi Z5 ; Arabloo J6 ; Bragazzi NL7 ; Behzadifar M8 ; Rashedi S9 ; Omidi N2 ; Ayoubian A10 ; Tajdini M2 ; Ghorashi SM2 ; Azari S1
Authors
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Authors Affiliations
  1. 1. Hospital Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Tehran Heart Center Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Library and Information Science, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  5. 5. National Institute of Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Canada
  8. 8. Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  9. 9. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. National Center for Health Insurance Research, Tehran, Iran

Source: IJC Heart and Vasculature Published:2022


Abstract

Since the SARS-CoV-2 pandemic began, numerous studies have reported a concerning drop in the number of acute myocardial infarction (AMI) admissions. In the present systematic review and meta-analysis, we aimed to compare the rate of AMI admissions and major complication during the pandemic, in comparison with pre-pandemic periods. Three major databases (PubMed, Scopus, and Web of Science Core Collection) were searched. Out of 314 articles, 41 were entered into the study. Patients hospitalized for AMI were 35% less in the COVID-19 era compared with pre-pandemic periods, which was statistically significantly (OR = 0.65; 95% CI: 0.56–0.74; I2 = 99%; p < 0.001; 28 studies). Patients hospitalized for STEMI and NSTEMI were 29% and 34% respectively less in the COVID-19 era compared with periods before COVID-19, which was statistically significantly (OR = 0.71; 95% CI: 0.65 –0.78; I2 = 93%; p < 0.001; 22 studies, OR = 0.66; 95% CI: 0.58–0.73; I2 = 95%; p < 0.001; 14 studies). The overall rate of in-hospital mortality in AMI patients increased by 26% in the COVID-19 era, which was not statistically significant (OR = 1.26; 95% CI: 1.0–1.59; I2 = 22%; p < 0.001; six studies). The rate of in-hospital mortality in STEMI and NSTEMI patients increased by 15% and 26% respectively in the COVID-19 era, which was not statistically significant (OR = 1.15; 95% CI: 0.85–1.57; I2 = 48%; p = 0.035; 11 studies, OR = 1.35; 95% CI: 0.64–2.86; I2 = 45%; p = 0.157; 3 articles). These observations highlight the challenges in the adaptation of health-care systems with the impact of the COVID-19 pandemic. © 2022
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