Antioxidant Capacity and Menopausal Symptoms Publisher



Sotoudeh G¹ ; Abshirini M² Show Affiliations
Source: Aging: Oxidative Stress and Dietary Antioxidants Published:2020

Abstract

Due to loss of the antioxidant effect of estrogen and decline in competence of the antioxidants system with aging, menopausal women are highly exposed to free radicals. Oxidative stress appears to be implicated in the pathological process linked to menopausal symptoms, and remarkable reduction of antioxidants status and elevated lipid peroxidation have been observed in the presence of severe climacteric symptoms. In this sense, modifying antioxidant protection through the intake of dietary supplements or following diets with high antioxidant content are suggested to be related to alleviation of symptoms. The existing clinical data on efficacy of antioxidant supplementation has been mixed, but evidence from observational studies has shown that adherence to diets with increased antioxidant content was related to fewer vasomotor symptoms and better psychological well-being in menopausal women. This review is focused on interaction of oxidative stress and menopause-associated symptoms and ability of dietary antioxidants or their supplements in counteracting it. © 2020 Elsevier Inc. All rights reserved.