White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness

White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness Publisher

Ashrafganjouei A¹ ; Kheiri G¹ ; Masoudi M¹ ; Mohajer B² ; Zadeh MM¹ ; Saberi P³ ; Shandiz MS⁴ ; Aarabi MH¹

Show Affiliations

1. Studentsâ€™ Scientific Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Radiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medical Physics, Zahedan University of Medical Sciences, Zahedan, Iran

Source: Frontiers in Neurology Published:2019

Abstract

Excessive daytime sleepiness (EDS) is relatively frequent in patients with Parkinson’s disease (PD), having a prominent burden on patients’ quality of life and causing dangerous events such as motor-vehicle accidents. Previous studies have indicated the role of certain neural tracts in the pathophysiology of sleep disturbances, especially in PD patients. We hypothesized that white matter integrity and connectivity might be altered in patients with PD and EDS. Therefore, this study investigated brain white matter microstructure alterations in patients with Parkinson’s disease with EDS (PD-EDS) compared to healthy controls and PD patients without EDS (PD-nEDS). Diffusion MRI connectometry was used to carry out group analysis between PD patients with and without EDS and healthy individuals. EDS in PD patients is associated with decreased connectivity in the left and right fornix, left and right inferior longitudinal fasciculus (ILF), left inferior and middle cerebellar peduncles in comparison to PD-nEDS group. These differences between PD-EDS and PD-nEDS patients reflects microstructural changes with respect to sleep-related circuits, which can pave the way for future investigations considering EDS pathogenesis in Parkinson’s disease. Copyright © 2019 Ashraf-Ganjouei, Kheiri, Masoudi, Mohajer, Mojtahed Zadeh, Saberi, Shirin Shandiz and Aarabi.

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Maryam Rahmani (1)

Style	Citing Format
MLA	Ashrafganjouei A, et al.. "White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness." Frontiers in Neurology, vol. 10, no. , 2019, pp. -.
APA	Ashrafganjouei A, Kheiri G, Masoudi M, Mohajer B, Zadeh MM, Saberi P, Shandiz MS, Aarabi MH (2019). White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness. Frontiers in Neurology, 10(), -.
Chicago	Ashrafganjouei A, Kheiri G, Masoudi M, Mohajer B, Zadeh MM, Saberi P, Shandiz MS, Aarabi MH. "White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness." Frontiers in Neurology 10, no. (2019): -.
Harvard	Ashrafganjouei A et al. (2019) 'White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness', Frontiers in Neurology, 10(), pp. -.
Vancouver	Ashrafganjouei A, Kheiri G, Masoudi M, Mohajer B, Zadeh MM, Saberi P, et al.. White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness. Frontiers in Neurology. 2019;10():-.
BibTex	@article{ author = {Ashrafganjouei A and Kheiri G and Masoudi M and Mohajer B and Zadeh MM and Saberi P and Shandiz MS and Aarabi MH}, title = {White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness}, journal = {Frontiers in Neurology}, volume = {10}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Ashrafganjouei A AU - Kheiri G AU - Masoudi M AU - Mohajer B AU - Zadeh MM AU - Saberi P AU - Shandiz MS AU - Aarabi MH TI - White Matter Tract Alterations in Drug-Naive Parkinson’S Disease Patients With Excessive Daytime Sleepiness JO - Frontiers in Neurology VL - 10 IS - SP - EP - PY - 2019 ER -

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