A Review of Senolytic Drugs in Reducing the Biological Problems of Aging; [مروری بر نقش داروهای سنولیتیک در کاهش مشکلات زیس تشناختی ناشی از پیری سلولی] Publisher



Assadiasl S^{1, 2} ; Safdel S¹ ; Nicknam MH^{1, 3} Show Affiliations
Source: Iranian Journal of Ageing Published:2025

Abstract

Objectives Considering the increase in the old adult population and age-related disorders, there is a need for strategies to reduce the complications of aging. Senolytic drugs might improve the function of tissues and organs in elderly people by destroying senescent cells. This review introduces different categories of senolytic drugs. Methods & Materials The keywords “Senolytic” and “Senolysis” were searched in PubMed, Scopus, and Google Scholar search engines. All original, review, and systematic review articles published between 2015 and 2023 were studied systematically. After the validation of data, 50 out of 108 articles were selected, and a summary of classifications and results was provided. Results Currently, 12 categories of senolytics, including kinase inhibitors, natural polyphenols, Bcl2 protein family inhibitors, P53 stabilizers, heat shock protein inhibitors, BET protein family inhibitors, cardiac steroids, PPARα agonists, antibiotics, integrase inhibitors, caloric restriction and chimeric antigen receptor cells have been introduced that are under study in different phases of preclinical or clinical research. Conclusion Considering the aging of the population, one of the strategies to deal with the debilitating effects of old age is senolytics, which can eliminate senescent cells with unfavorable function. The most studied categories with promising results include kinase enzymes and polyphenols, but novel strategies, such as specific targeting of senescent cells with CAR-T cells, are being developed. Copyright © 2025 The Author(s); This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC: https://creativecommons.org/licenses/by-nc/4.0/legalcode.en), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.