Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management

Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management Publisher

Taghizadehteymorloei M¹ ; Jafarlou V² ; Matin S^{3, 4} ; Raeisi M⁸ ; Roosta Y⁵ ; Mansouriderakhshani S⁶ ; Feizi AAH⁷ ; Karimi A¹

Show Affiliations

1. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Golgasht St., East Azerbaijan, Tabriz, 5166614756, Iran
2. Cancer Institute of Imam Khomeini Hospital, Tehran University of Medical Science, Tehran, Iran
3. Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
4. Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
5. Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
6. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Genetics, Tabriz, Iran
7. Hematology-Oncology Research Center, Tabriz University of Medical Sciences, Tabriz Children’s Hospital, Tabriz, Iran
8. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinical and Translational Oncology Published:2025

Abstract

Background: Colorectal cancer (CRC) remains a significant global health challenge, characterized by high morbidity and mortality rates. This study explores the potential of Alu-based cell-free DNA (cfDNA) and specific PIWI-interacting RNAs (piRNAs) as innovative biomarkers for monitoring treatment responses in CRC patients. Methods: We analyzed plasma samples from 70 CRC patients, equally divided between those undergoing chemotherapy and surgical interventions. Results: Our findings reveal that certain piRNAs, particularly piRNA-823, piRNA-54265, and piRNA-1245, exhibit significant prognostic value, with notable expression changes observed in the chemotherapy group compared to the surgery group. Furthermore, the levels of ALU-based cfDNA fragments showed a marked decrease post-chemotherapy, suggesting their utility in assessing therapeutic efficacy. Conclusions: This research underscores the importance of integrating these molecular tools particularly piRNA-823 and ALU-based cfDNA into clinical practice, potentially enhancing the management strategies for CRC patients and improving their outcomes. © The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO) 2025.

2. An Insight Into the Roles of Pirnas and Piwi Proteins in the Diagnosis and Pathogenesis of Oral, Esophageal, and Gastric Cancer, Pathology Research and Practice (2020)

3. Tumor-Educated Platelets, Clinica Chimica Acta (2024)

4. The Effects of Uvb and Vitamin D on Decreasing Risk of Colorectal Cancer Incidence and Mortality: A Review of the Epidemiology, Clinical Trials, and Mechanisms, Nutrition and Cancer (2019)

Experts (# of related papers)

Mohammad Ali Mansournia (1)

Style	Citing Format
MLA	Taghizadehteymorloei M, et al.. "Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management." Clinical and Translational Oncology, vol. , no. , 2025, pp. -.
APA	Taghizadehteymorloei M, Jafarlou V, Matin S, Raeisi M, Roosta Y, Mansouriderakhshani S, Feizi AAH, Karimi A (2025). Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management. Clinical and Translational Oncology, (), -.
Chicago	Taghizadehteymorloei M, Jafarlou V, Matin S, Raeisi M, Roosta Y, Mansouriderakhshani S, Feizi AAH, Karimi A. "Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management." Clinical and Translational Oncology , no. (2025): -.
Harvard	Taghizadehteymorloei M et al. (2025) 'Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management', Clinical and Translational Oncology, (), pp. -.
Vancouver	Taghizadehteymorloei M, Jafarlou V, Matin S, Raeisi M, Roosta Y, Mansouriderakhshani S, et al.. Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management. Clinical and Translational Oncology. 2025;():-.
BibTex	@article{ author = {Taghizadehteymorloei M and Jafarlou V and Matin S and Raeisi M and Roosta Y and Mansouriderakhshani S and Feizi AAH and Karimi A}, title = {Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management}, journal = {Clinical and Translational Oncology}, volume = {}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Taghizadehteymorloei M AU - Jafarlou V AU - Matin S AU - Raeisi M AU - Roosta Y AU - Mansouriderakhshani S AU - Feizi AAH AU - Karimi A TI - Clinical Implications of Alu-Based Cell-Free Dna and Serum Onco-Pirna Monitoring in Colorectal Cancer Management JO - Clinical and Translational Oncology VL - IS - SP - EP - PY - 2025 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract