The Relationship Between End Tidal Volume Carbon Dioxide Pressure and the Incidence and Severity of Nausea and Vomiting After General Anesthesia in Laparoscopic Cholecystectomy Publisher



K Naghibi KHOSROU ; Tt Hashemi Taghi TAGHI ; M Mianji MAHDI
Source: Journal of Isfahan Medical School Published:2025

Abstract

Background: Considering the complaints of some patients regarding the incidence of postoperative nausea and vomiting (PONV) after surgery and the role of end-tidal carbon dioxide levels, this study aimed to determine the effect of two different levels of end tidal carbon dioxide pressure on the incidence and severity of PONV in patients undergoing laparoscopic cholecystectomy under general anesthesia. Methods: In this clinical trial study, 88 patients aged 18–65 years were randomly divided into two groups. In the first group, end-tidal CO₂ pressure was maintained at 35–40 mmHg, and in the second group, at 40–45 mmHg. The incidence of nausea and vomiting was compared between the two groups at 2, 4, and 6 hours postoperatively in the recovery room. Data were analyzed using inferential statistical tests with a significance level of 5%. Findings: The frequency distribution of PONV and the number of vomiting episodes decreased non-significantly in both groups. The incidence of PONV in the first group decreased from 34% to 4.6% and in the second group from 40.9% to 6.8% within six hours after surgery. The frequency of vomiting decreased from 29.5% to 4.5% in the first group and from 31.8% to 6.8% in the second group. in all cases the difference between the two groups was not statistically significant. Conclusion: Since end-tidal CO₂ in the range of 35–45 mmHg had no effect on nausea and vomiting in patients undergoing LC under general anesthesia, further studies in this field are needed. © 2025 Elsevier B.V., All rights reserved.