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Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison With Hplc



Shahlaei M1 ; Hassanzadeh F2 ; Emami J3 ; Sohrabi E2 ; Saghaie L2
Authors
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Authors Affiliations
  1. 1. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Medicinal Chemistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Reports in Pharmaceutical Sciences Published:2013

Abstract

Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 μgml-1 to 170.130 μg ml-1 amlodipine and 13.7 μg ml-1 to 68.5 μgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations. © 2012 by Kermanshah University of Medical Sciences.
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