Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats

Isfahan University of Medical Sciences

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Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats Publisher Pubmed

Ahmadi M¹ ; Rajaei Z² ; Hadjzadeh MA¹ ; Nemati H¹ ; Hosseini M¹

Show Affiliations

1. Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Isfahan, Iran
2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neuroscience Letters Published:2017

Abstract

The purpose of the current study was to examine the influence of crocin on improving spatial memory deficits and cerebral oxidative damage in streptozotocin-induced diabetic rats. Crocin was administered intraperitoneally daily at doses of 15, 30 and 60 mg/kg for 6 weeks. Spatial memory performance was measured in rats by the Morris water maze paradigm. Lipid peroxidation and total thiol levels as parameters of oxidative stress were assessed in the cerebral cortex at the end of week 6. Diabetic rats showed spatial learning and memory deficits in the Morris water maze which was accompanied by increased lipid peroxidation levels in the cerebral cortex. By contrast, chronic treatment with crocin (15, 30 and 60 mg/kg, ip, 6 weeks) improved cognitive performance and lowered hyperglycaemia and oxidative stress in diabetic rats. In conclusion, the results suggest that beneficial effects of crocin on streptozotocin-induced memory dysfunction may be attributed to its antidiabetic and antioxidant activity, which could find clinical use in treating cognitive dysfunction in diabetics. © 2017 Elsevier B.V.

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Style	Citing Format
MLA	Ahmadi M, et al.. "Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats." Neuroscience Letters, vol. 642, no. , 2017, pp. 1-6.
APA	Ahmadi M, Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M (2017). Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats. Neuroscience Letters, 642(), 1-6.
Chicago	Ahmadi M, Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M. "Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats." Neuroscience Letters 642, no. (2017): 1-6.
Harvard	Ahmadi M et al. (2017) 'Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats', Neuroscience Letters, 642(), pp. 1-6.
Vancouver	Ahmadi M, Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M. Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats. Neuroscience Letters. 2017;642():1-6.
BibTex	@article{ author = {Ahmadi M and Rajaei Z and Hadjzadeh MA and Nemati H and Hosseini M}, title = {Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats}, journal = {Neuroscience Letters}, volume = {642}, number = {}, pages = {1-6}, year = {2017} }
RIS	TY - JOUR AU - Ahmadi M AU - Rajaei Z AU - Hadjzadeh MA AU - Nemati H AU - Hosseini M TI - Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats JO - Neuroscience Letters VL - 642 IS - SP - 1 EP - 6 PY - 2017 ER -