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The Clinical Approach Toward Hereditary Persistence of Fetal Hemoglobin: A Case Report Publisher Pubmed



Ghaderi A1 ; Bakhtiari T2 ; Jokar S3 ; Eshraghi A4
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Hematology and Medical Oncology Ward, Yasuj University of Medical Sciences, Yasuj, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, Shahids Rajaee Hospital of Gachsaran, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran

Source: Iranian Journal of Allergy, Asthma and Immunology Published:2022


Abstract

Fetal hemoglobin is the principal hemoglobin in the human fetus, and the adult levels of fetal hemoglobin (HbF) are less than 1% of total hemoglobin. A steady increase of HbF in patients with hereditary persistence of fetal hemoglobin (HPFH) is associated with complications. The present report describes HPFH in a 26-year-old man with emphasis on its hemoglobin electrophoresis. The patient was admitted with complaints of recurrent weakness and lethargy, weight loss, abdominal pain, and dyspepsia. Splenectomy was planned due to massive splenomegaly and gastrointestinal complications. Ultimately, electrophoresis confirmed the diagnosis of HPFH. Copyright © 2022 Ghaderi et al. Published by Tehran University of Medical Sciences.
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