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The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients Publisher Pubmed



Gheybi MK1 ; Farrokhi S2 ; Ravanbod MR3 ; Ostovar A4 ; Mehrzad V5 ; Nematollahi P6
Authors

Source: Breast Cancer Published:2017


Abstract

Background: T regulatory cells (Tregs) are known to negatively control immune response. The frequency of these cells was inversely correlated with clinical outcomes of breast cancer. CD19+CD24hiCD38hi cells also play a critical role in inflammation and autoimmune disease. However, their function in tumor immune response is less studied. In this study we aimed to determine the role of CD19+CD24hiCD38hi cells and some other clinicopathological variables in increasing the proportion of Tregs in breast cancer patients. Methods: We selected 47 patients with invasive ductal breast carcinoma and 50 healthy controls and obtained their blood samples. Results: The proportion of circulating CD4+CD25+Foxp3+ Tregs and CD19+CD24hiCD38hi cells was significantly increased in breast cancer patients. We also found that increased proportion of Tregs in breast cancer is correlated with HER2 amplification, advanced clinical stages, serum TGF-β1 and increased CD19+CD24hiCD38hi cells in the peripheral blood. Conclusion: Altogether, our data suggest that as much as Tregs, CD19+CD24hiCD38hi B cells could also have a part in the suppression of immune response in breast cancer. © 2017, The Japanese Breast Cancer Society.
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