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Recurrent Multiple Myeloma Following Renal Transplantation: A Case Report Publisher Pubmed



Taheri D1 ; Chehrei A1 ; Fesharakizadeh M2 ; Seyrafean S3 ; Shahidi S3 ; Emami A3 ; Taheri S3 ; Azani M4
Authors

Source: Transplantation Proceedings Published:2007


Abstract

Renal transplantation is generally not considered for patients with multiple myeloma (MM) because of their extremely poor prognosis. However, for patients in remission, it offers an alternative to dialysis. There are few reports of MM recurrence among kidney transplant recipients. We report a 57-year-old white man with end-stage renal disease (ESRD) and known multiple myeloma in remission who underwent kidney transplantation. Eighteen months after transplantation upon routine follow-up, he was observed to have an elevated creatinine with no evidence of recurrence of myeloma upon bone marrow aspiration. Light microscopy and immunoflorescence of a renal biopsy showed chronic scarring of the kidney owing to cast nephropathy consistent with MM recurrence. Repeat bone marrow aspiration 1 week later confirmed this diagnosis. A review of the literature of prior studies suggested that it is reasonable to perform renal transplantation in patients with ESRD due to MM in remission, but large prospective studies would help to develop a strategy for prevention of multiple myeloma recurrence. © 2007 Elsevier Inc. All rights reserved.
1. Outcome of Patients Without Any Immunosuppressive Therapy After Renal Allograft Failure., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2008)
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