Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk

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Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk Publisher Pubmed

Nolte IM¹ ; Munoz ML¹ ; Tragante V² ; Amare AT^{1, 3, 4} ; Jansen R⁵ ; Vaez A^{1, 6} ; Von Der Heyde B^{7, 8} ; Avery CL⁹ ; Bis JC¹⁰ ; Dierckx B^{11, 12} ; Van Dongen J¹³ ; Gogarten SM¹⁴ ; Goyette P¹⁵ ; Hernesniemi J^{16, 17, 18} Show All Authors

Nolte IM¹
Munoz ML¹
Tragante V²
Amare AT^{1, 3, 4}
Jansen R⁵
Vaez A^{1, 6}
Von Der Heyde B^{7, 8}
Avery CL⁹
Bis JC¹⁰
Dierckx B^{11, 12}
Van Dongen J¹³
Gogarten SM¹⁴
Goyette P¹⁵
Hernesniemi J^{16, 17, 18}
Huikari V¹⁹
Hwang SJ^{20, 21}
Jaju D²²
Kerr KF¹⁴
Kluttig A²³
Krijthe BP²⁴
Kumar J^{7, 8}
Van Der Laan SW²⁵
Lyytikainen LP^{16, 17}
Maihofer AX^{26, 27}
Minassian A^{26, 27}
Van Der Most PJ¹
Mullernurasyid M^{28, 29, 30}
Nivard M^{13, 31}
Salvi E³²
Stewart JD^{9, 33}
Thayer JF³⁴
Verweij N³⁵
Wong A³⁶
Zabaneh D^{37, 38}
Zafarmand MH^{39, 40}
Abdellaoui A^{13, 31}
Albarwani S⁴¹
Albert C⁴²
Alonso A⁴³
Ashar F⁴⁴
Auvinen J⁴⁵
Axelsson T⁴⁶
Baker DG^{26, 27}
De Bakker PIW^{47, 48}
Barcella M³²
Bayoumi R⁴⁹
Bieringa RJ¹
Boomsma D^{13, 31}
Boucher G¹⁵
Britton AR⁵⁰
Christophersen IE^{51, 52, 53}
Dietrich A⁵⁴
Ehret GB^{55, 56}
Ellinor PT^{52, 57}
Eskola M^{18, 58}
Felix JF²⁴
Floras JS^{59, 60}
Franco OH²⁴
Friberg P⁶¹
Gademan MGJ³⁹
Geyer MA²⁶
Giedraitis V⁶²
Hartman CA⁶³
Hemerich D^{2, 64}
Hofman A²⁴
Hottenga JJ^{13, 31}
Huikuri H⁶⁵
Hutrikahonen N^{66, 67}
Jouven X⁶⁸
Junttila J⁶⁵
Juonala M^{69, 70}
Kiviniemi AM⁶⁵
Kors JA⁷¹
Kumari M^{50, 72}
Kuznetsova T⁷³
Laurie CC¹⁴
Lefrandt JD⁷⁴
Li Y⁷⁵
Li Y⁷⁵
Liao D⁷⁹
Limacher MC⁸⁰
Lin HJ^{81, 82}
Lindgren CM^{83, 84}
Lubitz SA^{52, 57}
Mahajan A⁸⁴
Mcknight B^{10, 14, 85}
Meyer Zu Schwabedissen H⁸⁶
Milaneschi Y⁵
Mononen N^{16, 17}
Morris AP^{84, 87}
Nalls MA⁸⁸
Navis G⁸⁹
Neijts M^{13, 31}
Nikus K^{18, 90}
North KE^{9, 91}
Oconnor DT⁹²
Ormel J⁶³
Perz S⁹³
Peters A^{30, 93, 94}
Psaty BM^{10, 95, 96}
Raitakari OT^{97, 98}
Risbrough VB^{26, 27}
Sinner MF^{29, 30}
Siscovick D⁹⁹
Smit JH⁵
Smith NL^{96, 100, 101}
Soliman EZ¹⁰²
Sotoodehnia N¹⁰³
Staessen JA⁷³
Stein PK¹⁰⁴
Stilp AM¹⁴
Stolarzskrzypek K¹⁰⁵
Strauch K^{28, 106}
Sundstrom J¹⁰⁷
Swenne CA¹⁰⁸
Syvanen AC⁴⁶
Tardif JC^{15, 109}
Taylor KD¹¹⁰
Teumer A¹¹¹
Thornton TA¹⁴
Tinker LE⁸⁵
Uitterlinden AG^{24, 112, 113}
Van Setten J²
Voss A¹¹⁴
Waldenberger M^{93, 115}
Wilhelmsen KC^{116, 117}
Willemsen G^{13, 31}
Wong Q¹⁴
Zhang ZM^{102, 118}
Zonderman AB¹¹⁹
Cusi D^{120, 121}
Evans MK¹¹⁹
Greiser HK¹²²
Van Der Harst P³⁵
Hassan M⁴¹
Ingelsson E^{7, 8, 123}
Jarvelin MR^{19, 45, 124, 125}
Kaab S^{29, 30}
Kahonen M^{126, 127}
Kivimaki M⁵⁰
Kooperberg C⁸⁵
Kuh D³⁶
Lehtimaki T^{16, 17}
Lind L¹⁰⁷
Nievergelt CM^{26, 27}
Odonnell CJ^{20, 21, 128}
Oldehinkel AJ⁶³
Penninx B⁵
Reiner AP^{85, 100}
Riese H⁶³
Van Roon AM⁷⁴
Rioux JD^{15, 109}
Rotter JI¹¹⁰
Sofer T¹⁴
Stricker BH^{24, 129}
Tiemeier H^{11, 24}
Vrijkotte TGM³⁹
Asselbergs FW^{2, 130, 131}
Brundel BJJM¹³²
Heckbert SR^{10, 100}
Whitsel EA^{9, 133}
Den Hoed M^{7, 8}
Snieder H¹
De Geus EJC^{13, 31}

Source: Nature Communications Published:2017

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74

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Style	Citing Format
MLA	Nolte IM, et al.. "Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk." Nature Communications, vol. 8, no. , 2017, pp. -.
APA	Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, Von Der Heyde B, Avery CL, Bis JC, Dierckx B, Van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, ... De Geus EJC (2017). Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk. Nature Communications, 8(), -.
Chicago	Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, Von Der Heyde B, et al.. "Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk." Nature Communications 8, no. (2017): -.
Harvard	Nolte IM et al. (2017) 'Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk', Nature Communications, 8(), pp. -.
Vancouver	Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, et al.. Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk. Nature Communications. 2017;8():-.
BibTex	@article{ author = {Nolte IM and Munoz ML and Tragante V and Amare AT and Jansen R and Vaez A and Von Der Heyde B and Avery CL and Bis JC and Dierckx B and Van Dongen J and Gogarten SM and Goyette P and Hernesniemi J and Huikari V and Hwang SJ and Jaju D and Kerr KF and Kluttig A and Krijthe BP and Kumar J and Van Der Laan SW and Lyytikainen LP and Maihofer AX and Minassian A and Van Der Most PJ and Mullernurasyid M and Nivard M and Salvi E and Stewart JD and Thayer JF and Verweij N and Wong A and Zabaneh D and Zafarmand MH and Abdellaoui A and Albarwani S and Albert C and Alonso A and Ashar F and Auvinen J and Axelsson T and Baker DG and De Bakker PIW and Barcella M and Bayoumi R and Bieringa RJ and Boomsma D and Boucher G and Britton AR and Christophersen IE and Dietrich A and Ehret GB and Ellinor PT and Eskola M and Felix JF and Floras JS and Franco OH and Friberg P and Gademan MGJ and Geyer MA and Giedraitis V and Hartman CA and Hemerich D and Hofman A and Hottenga JJ and Huikuri H and Hutrikahonen N and Jouven X and Junttila J and Juonala M and Kiviniemi AM and Kors JA and Kumari M and Kuznetsova T and Laurie CC and Lefrandt JD and Li Y and Li Y and Liao D and Limacher MC and Lin HJ and Lindgren CM and Lubitz SA and Mahajan A and Mcknight B and Meyer Zu Schwabedissen H and Milaneschi Y and Mononen N and Morris AP and Nalls MA and Navis G and Neijts M and Nikus K and North KE and Oconnor DT and Ormel J and Perz S and Peters A and Psaty BM and Raitakari OT and Risbrough VB and Sinner MF and Siscovick D and Smit JH and Smith NL and Soliman EZ and Sotoodehnia N and Staessen JA and Stein PK and Stilp AM and Stolarzskrzypek K and Strauch K and Sundstrom J and Swenne CA and Syvanen AC and Tardif JC and Taylor KD and Teumer A and Thornton TA and Tinker LE and Uitterlinden AG and Van Setten J and Voss A and Waldenberger M and Wilhelmsen KC and Willemsen G and Wong Q and Zhang ZM and Zonderman AB and Cusi D and Evans MK and Greiser HK and Van Der Harst P and Hassan M and Ingelsson E and Jarvelin MR and Kaab S and Kahonen M and Kivimaki M and Kooperberg C and Kuh D and Lehtimaki T and Lind L and Nievergelt CM and Odonnell CJ and Oldehinkel AJ and Penninx B and Reiner AP and Riese H and Van Roon AM and Rioux JD and Rotter JI and Sofer T and Stricker BH and Tiemeier H and Vrijkotte TGM and Asselbergs FW and Brundel BJJM and Heckbert SR and Whitsel EA and Den Hoed M and Snieder H and De Geus EJC}, title = {Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk}, journal = {Nature Communications}, volume = {8}, number = {}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Nolte IM AU - Munoz ML AU - Tragante V AU - Amare AT AU - Jansen R AU - Vaez A AU - Von Der Heyde B AU - Avery CL AU - Bis JC AU - Dierckx B AU - Van Dongen J AU - Gogarten SM AU - Goyette P AU - Hernesniemi J AU - Huikari V AU - Hwang SJ AU - Jaju D AU - Kerr KF AU - Kluttig A AU - Krijthe BP AU - Kumar J AU - Van Der Laan SW AU - Lyytikainen LP AU - Maihofer AX AU - Minassian A AU - Van Der Most PJ AU - Mullernurasyid M AU - Nivard M AU - Salvi E AU - Stewart JD AU - Thayer JF AU - Verweij N AU - Wong A AU - Zabaneh D AU - Zafarmand MH AU - Abdellaoui A AU - Albarwani S AU - Albert C AU - Alonso A AU - Ashar F AU - Auvinen J AU - Axelsson T AU - Baker DG AU - De Bakker PIW AU - Barcella M AU - Bayoumi R AU - Bieringa RJ AU - Boomsma D AU - Boucher G AU - Britton AR AU - Christophersen IE AU - Dietrich A AU - Ehret GB AU - Ellinor PT AU - Eskola M AU - Felix JF AU - Floras JS AU - Franco OH AU - Friberg P AU - Gademan MGJ AU - Geyer MA AU - Giedraitis V AU - Hartman CA AU - Hemerich D AU - Hofman A AU - Hottenga JJ AU - Huikuri H AU - Hutrikahonen N AU - Jouven X AU - Junttila J AU - Juonala M AU - Kiviniemi AM AU - Kors JA AU - Kumari M AU - Kuznetsova T AU - Laurie CC AU - Lefrandt JD AU - Li Y AU - Li Y AU - Liao D AU - Limacher MC AU - Lin HJ AU - Lindgren CM AU - Lubitz SA AU - Mahajan A AU - Mcknight B AU - Meyer Zu Schwabedissen H AU - Milaneschi Y AU - Mononen N AU - Morris AP AU - Nalls MA AU - Navis G AU - Neijts M AU - Nikus K AU - North KE AU - Oconnor DT AU - Ormel J AU - Perz S AU - Peters A AU - Psaty BM AU - Raitakari OT AU - Risbrough VB AU - Sinner MF AU - Siscovick D AU - Smit JH AU - Smith NL AU - Soliman EZ AU - Sotoodehnia N AU - Staessen JA AU - Stein PK AU - Stilp AM AU - Stolarzskrzypek K AU - Strauch K AU - Sundstrom J AU - Swenne CA AU - Syvanen AC AU - Tardif JC AU - Taylor KD AU - Teumer A AU - Thornton TA AU - Tinker LE AU - Uitterlinden AG AU - Van Setten J AU - Voss A AU - Waldenberger M AU - Wilhelmsen KC AU - Willemsen G AU - Wong Q AU - Zhang ZM AU - Zonderman AB AU - Cusi D AU - Evans MK AU - Greiser HK AU - Van Der Harst P AU - Hassan M AU - Ingelsson E AU - Jarvelin MR AU - Kaab S AU - Kahonen M AU - Kivimaki M AU - Kooperberg C AU - Kuh D AU - Lehtimaki T AU - Lind L AU - Nievergelt CM AU - Odonnell CJ AU - Oldehinkel AJ AU - Penninx B AU - Reiner AP AU - Riese H AU - Van Roon AM AU - Rioux JD AU - Rotter JI AU - Sofer T AU - Stricker BH AU - Tiemeier H AU - Vrijkotte TGM AU - Asselbergs FW AU - Brundel BJJM AU - Heckbert SR AU - Whitsel EA AU - Den Hoed M AU - Snieder H AU - De Geus EJC TI - Genetic Loci Associated With Heart Rate Variability and Their Effects on Cardiac Disease Risk JO - Nature Communications VL - 8 IS - SP - EP - PY - 2017 ER -