Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Factors Affecting Mortality in Covid-19-Associated Pulmonary Aspergillosis: An International Id-Iri Study Publisher

Summary: Study links older age and organ failure to higher death risk in COVID-19 lung infections, urging early intervention. #COVID19 #InfectiousDisease

Sahin M1 ; Yilmaz M1 ; Mert A1 ; Emecen AN2 ; Rahman S Al Maslamani MA3 ; Mahmoud A Hashim S3 ; Ittaman AV3 ; Wadi Al Ramahi J4 ; Gergely Szabo B5 ; Konopnicki D6 ; Baskol Elik D7 ; Lakatos B5 ; Sipahi OR7 ; Khedr R8 Show All Authors
Authors
  1. Sahin M1
  2. Yilmaz M1
  3. Mert A1
  4. Emecen AN2
  5. Rahman S Al Maslamani MA3
  6. Mahmoud A Hashim S3
  7. Ittaman AV3
  8. Wadi Al Ramahi J4
  9. Gergely Szabo B5
  10. Konopnicki D6
  11. Baskol Elik D7
  12. Lakatos B5
  13. Sipahi OR7
  14. Khedr R8
  15. Jalal S9
  16. Pshenichnaya N10
  17. Magdalena DI11
  18. Elkholy A12
  19. Khan EA13
  20. Alkan S14
  21. Hakamifard A15
  22. Sincan G16
  23. Esmaoglu A17
  24. Makek MJ18, 19
  25. Gurbuz E20
  26. Liskova A21
  27. Albayrak A22
  28. Stebel R23
  29. Unver Ulusoy T24
  30. Ripon RK25
  31. Moroti R26, 27
  32. Dascalu C26
  33. Rashid N13
  34. Cortegiani A28
  35. Bahadir Z29
  36. Erdem H30

Source: Heliyon Published:2024


Abstract

Background: This study aimed to identify factors that influence the mortality rate of patients with coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA). Methods: In this cross-sectional study, data from 23 centers across 15 countries, spanning the period of March 2020 to December 2021, were retrospectively collected. The study population comprised patients who developed invasive pulmonary aspergillosis while being treated for COVID-19 in the intensive care unit. Cox regression and decision tree analyses were used to identify factors associated with mortality in patients with CAPA. Results: A total of 162 patients (males, 65.4 %; median age: 64 [25th–75th: 54.0–73.8] years) were included in the study, of whom 113 died during the 90-day follow-up period. The median duration from CAPA diagnosis to death was 12 (25th–75th: 7–19) days. In the multivariable Cox regression model, an age of ≥65 years (hazard ratio [HR]: 2.05, 95 % confidence interval [CI]: 1.37–3.07), requiring vasopressor therapy at the time of CAPA diagnosis (HR: 1.80, 95 % CI: 1.17–2.76), and receiving renal replacement therapy at the time of CAPA diagnosis (HR: 2.27, 95 % CI: 1.35–3.82) were identified as predictors of mortality. Decision tree analysis revealed that patients with CAPA aged ≥65 years who received corticosteroid treatment for COVID-19 displayed higher mortality rates (estimated rate: 1.6, observed in 46 % of patients). Conclusion: This study concluded that elderly patients with CAPA who receive corticosteroids are at a significantly higher risk of mortality, particularly if they experience multiorgan failure. © 2024
Other Related Docs
20. Epidemiological Features of Covid-19 in Iran, Journal of Research in Medical Sciences (2022)