Comparing the Effects of Botulinum Toxin-A and Cetirizine on the Treatment of Allergic Rhinitis Publisher



Hashemi SM¹ ; Okhovat A¹ ; Amini S¹ ; Pourghasemian M¹ Show Affiliations
Source: Allergology International Published:2013

Abstract

Background: There are few reports on the effects of intranasal Botulinum Toxin-A (BTX-A) as a treatment of allergic rhinitis (AR). In this study, we compared the efficacy of intranasal BTX-A to cetirizine in the treatment of AR. Methods: Fifty AR patients at the age of 26.2 ± 9.1 years (64% females), were recruited to the trial according to the Allergic Rhinitis and its Impact on Asthma (ARIA) criteria. Participants randomly received either intranasal injection of BTX-A (75 IU Dyspor® or cetirizine (10 mg/day). Symptoms (based on the ARIA) and side effects were assessed every two weeks for two months. Quality of life was evaluated before and after the study using the Rhinasthma questionnaire. Results: Total symptom severity score of patients significantly decreased (P < 0.001) and quality of life signifi-cantly improved (P < 0.001) at the same level in both groups. Side effects included nasal dryness (4%) and epistaxis (4%) in the BTX-A group. In the cetirizine group 44% sleepiness and 4% blurred vision was reported. Conclusions: Nasal injection of BTX-A shows the same therapeutic effects as cetirizine in the management of AR. Since BTX is expensive, we do not suggest it in the first line of treatment for AR. However, BTX-A is a potential treatment for patients who are resistant or not compliant to the routine medications of AR. Further studies are required to investigate implications and limitations of BTX-A in the treatment of AR. © 2013 Japanese Society of Allergology.