Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
High Prevalence of Sars-Coronavirus-2 in Patients With Inflammatory Bowel Disease and the Role of Soluble Angiotensin Converting Enzyme2 Publisher Pubmed

Summary: Study finds 20% of IBD patients had COVID-19 antibodies, with higher ACE2 levels. #IBD #COVID19

Shahrokh S1 ; Baradaran Ghavami S1 ; Asadzadeh Aghdaei H1 ; Parigi TL2, 3 ; Farmani M1 ; Danese S2, 4 ; Ebrahimi Daryani N5 ; Vossoughinia H6 ; Balaii H1 ; Alborzi F5 ; Khoramjoo SM1 ; Khanabadi B1 ; Seyed Salehi A1 ; Bastani A7 Show All Authors
Authors
  1. Shahrokh S1
  2. Baradaran Ghavami S1
  3. Asadzadeh Aghdaei H1
  4. Parigi TL2, 3
  5. Farmani M1
  6. Danese S2, 4
  7. Ebrahimi Daryani N5
  8. Vossoughinia H6
  9. Balaii H1
  10. Alborzi F5
  11. Khoramjoo SM1
  12. Khanabadi B1
  13. Seyed Salehi A1
  14. Bastani A7
  15. Sharifi M8
  16. Safari MT1
  17. Malekpour H1
  18. Sherkat G9
  19. Saberafsharian M10
  20. Miri MB11
  21. Moosavi SH11
  22. Anaraki F12
  23. Nazemalhosseinimojarad E1
  24. Mohebbi SR1
  25. Shojaie S1
  26. Pourhoseingholi MA1
  27. Zali MR1

Source: Archives of Physiology and Biochemistry Published:2024


Abstract

Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection. Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study. Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test. Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Gastrointestinal and Renal Complications in Sars-Cov-2-Infected Patients: Role of Immune System, Scandinavian Journal of Immunology (2021)
2. Evaluation of Angiotensin Converting Enzyme 2 (Ace2), Angiotensin Ii (Ang Ii), Mir-141-3P, and Mir-421 Levels in Sars-Cov-2 Patients: A Case-Control Study, BMC Infectious Diseases (2024)
3. Clinical Symptoms of Covid-19 and Their Association With Disease Outcome, Advanced Biomedical Research (2022)
Experts (# of related papers)
View all Related Experts
Mohammad Hassan Emami (2)
Peyman Adibi (2)
High Prevalence of Sars-Coronavirus-2 in Patients With Inflammatory Bowel Disease and the Role of Soluble Angiotensin Converting Enzyme2
Other Related Docs
4. Serologic Celiac Disease in Patients With Inflammatory Bowel Disease, Journal of Research in Medical Sciences (2012)
5. Liver and Kidney Injuries in Covid-19 and Their Effects on Drug Therapy; a Letter to Editor, Archives of Academic Emergency Medicine (2020)
6. D-Dimer Levels in Predicting Severity of Infection and Outcome in Patients With Covid-19, Tanaffos (2022)
7. Ibd Genomic Risk Loci and Overlap With Other Inflammatory Diseases, Molecular Genetics of Inflammatory Bowel Disease (2019)
8. Sars-Cov-2 Antibody Seroprevalence in the General Population and High-Risk Occupational Groups Across 18 Cities in Iran: A Population-Based Cross-Sectional Study, The Lancet Infectious Diseases (2021)
9. Very Early Onset Inflammatory Bowel Disease: Investigation of the Il-10 Signaling Pathway in Iranian Children, European Journal of Medical Genetics (2017)
10. Diagnostic Value of Natural Killer Cells, Cd56+ Cd16+ Natural Killer Cells, Nlrp3, and Lactate Dehydrogenase in Severe/Critical Covid-19: A Prospective Longitudinal Study According to the Severe/Critical Covid-19 Definitions, Viral Immunology (2022)
11. Iranian Registry of Crohn’S and Colitis: Study Profile of First Nation-Wide Inflammatory Bowel Disease Registry in Middle East, Intestinal Research (2019)
12. Coronavirus Disease-19 (Covid-19) Presenting With Severe Acute Pancreatitis: A Case Report From Iran, Journal of Advances in Medical and Biomedical Research (2022)
13. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)
14. Comparison the Effects and Side Effects of Covid-19 Vaccination in Patients With Inflammatory Bowel Disease (Ibd): A Systematic Scoping Review, BMC Gastroenterology (2022)
15. Nervous System Involvement in Covid-19: A Review of the Current Knowledge, Molecular Neurobiology (2021)
16. Human Microbiome in Post-Acute Covid-19 Syndrome (Pacs), Current Research in Microbial Sciences (2025)
17. Genomic Testing Identifies Monogenic Causes in Patients With Very Early-Onset Inflammatory Bowel Disease: A Multicenter Survey in an Iranian Cohort, Clinical and Experimental Immunology (2024)
18. Association of Rasis and Hmg-Coa Reductase Inhibitors With Clinical Manifestations in Coronavirus Disease 2019 Patients: Results From the Khorshid Coronavirus Disease Cohort Study, Journal of Research in Medical Sciences (2023)
19. Correlation of Expression of Mmp-2, Ace2, and Tmprss2 Genes With Lymphopenia for Mild and Severity of Covid-19, Iranian Journal of Allergy, Asthma and Immunology (2023)
20. Clinical Characteristics of Covid-19-Infected Cancer Patients, Isfahan, Iran, Journal of Research in Medical Sciences (2022)