Central and Peripheral Anti-Inflammatory Effects of Maprotiline on Carrageenan-Induced Paw Edema in Rats Publisher Pubmed



Hajhashemi V¹ ; Minaiyan M¹ ; Movahedian A² ; Talebi A³ Show Affiliations
Source: Inflammation Research Published:2010

Abstract

Objective: To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema. Subjects Male Wistar rats were used. Methods: Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg-1) was assessed using a paw edema model. Secondly, different doses of maprotiline were administrated intracerebroventricularly, intrathecally and locally before carrageenan challenge. Finally, we tried to reverse the anti-inflammatory effect of maprotiline by propranolol (10 mg kg-1), prazosin (4 mg kg -1), yohimbine (10 mg kg-1), naloxone (4 mg kg -1) and mifepristone (5 mg kg-1). Results Systemic, intracerebroventricular and subplantar application of maprotiline significantly inhibited peripheral edema, but intrathecal maprotiline did not alter the degree of paw swelling. The applied antagonists failed to change the anti-inflammatory activity of maprotiline. Conclusion These results demonstrate that maprotiline has a potent anti-inflammatory effect and this effect is linked to the peripheral and supraspinal actions of the drug. © Springer Basel AG 2010.