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Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry Publisher



A Attar ARMIN ; M Sayadi MEHRAB ; A Hosseinpour ALIREZA ; Es Brilakis Emmanouil S ; F Mehdizade FERESHTE ; Z Namvar ZAHRA ; A Khosravifarsani ALIREZA ; M Boshtam MARYAM ; F Noohi FERIDOUN ; Ar Assareh Ahmadreza REZA
Authors

Source: Health Science Reports Published:2025


Abstract

Background and Aims: The prevalence of coronary chronic total occlusions (CTO) among patients with chronic coronary syndrome (CCS) and their associations with clinical factors have received limited study. We analyzed a national database registry to determine the prevalence, location, and parameters associated with coronary CTOs. Methods: We identified all CCS patients without prior coronary artery bypass graft surgery (CABG) who underwent coronary angiography in the Persian CardioVascular Disease Registry (PCVDR). We compared the baseline demographics and characteristics of patients with vs. without at least one CTO lesion. We used logistic regression analysis to identify parameters associated with coronary CTOs. Results: Among the 40,161 patients with CCS who underwent coronary angiography between March 2019 and December 2023, 6805 (17.86%) had at least one CTO. CTO patients were significantly older (64.43 ± 8.96 years vs. 62.64 ± 9.54 years, p < 0.001) and more likely to be men (75.3% vs. 54.4%, p < 0.001). The left anterior descending artery (70.4%) and right coronary artery (16.5%) were the most common CTO lesion locations. Older age (adjusted odds ratio [aOR] 95% confidence intervals [CI] 1.024 (1.021–1.028), male gender (aOR 2.865 (2.685–3.058), any smoking (aOR 1.256 (1.145–1.378), diabetes mellitus (aOR 1.372 (1.288–1.460), and dyslipidemia (aOR 1.166 (1.096–1.239) were independently associated with the presence of a CTO. Conclusion: Approximately 1 in 5 CCS patients without prior CABG undergoing coronary angiography in this national database registry had a CTO. Advanced age, male gender, history of smoking, diabetes mellitus, and dyslipidemia were associated with higher likelihood of coronary CTOs. © 2025 Elsevier B.V., All rights reserved.
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