Viral Infection in Endometritis: Is There an Important Role or Not? Publisher Pubmed

Summary: A study suggests viral infections may trigger chronic endometritis, impacting fertility by altering the endometrial environment. #Fertility #Endometritis

Tehrani HG¹ ; Rezaei M¹ ; Mehrabian F¹ ; Naghshineh E¹ ; Moghoofei M^{2, 3}
Source: American Journal of Reproductive Immunology Published:2024

Abstract

Chronic endometritis (CE) is a frequent pathological condition that is defined as localized inflammation in the endometrium. Some adverse fertility consequences such as recurrent miscarriage and failure of implantation are associated with chronic endometritis. On the one hand, inflammation plays an important role in the pathogenesis of endometritis, and on the other hand, the role of viral infections in inducing inflammation can make this review strongly attractive and practical. We set out to provide an overview of viral infections as a potential etiology of CE pathophysiology through the alteration of an endometrial microenvironment and its association with infertility. To the best of our knowledge, this is the first review to demonstrate the role of viral infection in chronic endometritis, and whether or not infection ultimately plays a role. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.