Rock1 Is Associated With Non-Syndromic Cleft Palate

Rock1 Is Associated With Non-Syndromic Cleft Palate Publisher Pubmed

Palmieri A¹ ; Scapoli L¹ ; Carrozzo M² ; Cura F³ ; Morselli PG^{1, 4} ; Pannuto L⁴ ; Nouri N^{5, 6} ; Carinci F³ ; Lauritano D⁷ ; Martinelli M¹

Show Affiliations

1. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
2. School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
3. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
4. Plastic Surgery Unit, University Hospital of Bologna Sant'Orsola Malpighi Polyclinic, Bologna, Italy
5. Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6. Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
7. Department of Medicine and Surgery, Centre of Neuroscience of Milan, University of Milano-Bicocca, Milan, Italy

Source: Journal of Oral Pathology and Medicine Published:2020

Abstract

Background: Craniofacial morphogenesis is the result of an intricate multistep network of tightly controlled spatial and temporal signalling that involves several molecules and transcription factors organized into highly coordinated pathways. Any alteration in even one step of this delicate process can lead to congenital malformations such as cleft palate. One of the first steps in embryonal orofacial development is the migration of cells from the neural crests to the branchial arches. Next, the cells have to proliferate, differentiate, move and connect to each other in order to correctly form the palate. Cell contraction, promoted by the interaction of non-muscle myosin II and actin A, is a crucial step in morphogenesis and is regulated by ROCK1 protein. Methods: A family-based association study was carried out in order to verify whether or not genetic variants of ROCK1 were associated with non-syndromic cleft palate (nsCP). Two cohorts from Italy and Iran, a total of 189 nsCP cases and their parents were enrolled. Results: The rs35996865-G allele was under-transmitted in cases of nsCP [P =.006, odds ratio (OR) = 0.63 (95% CI 0.45-0.88)]. Conclusion: This investigation reveals for the first time data supporting a role for ROCK1 in nsCP aetiology. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

2. Ultra-Rare Variants Identify Biological Pathways and Candidate Genes in the Pathobiology of Non-Syndromic Cleft Palate Only, Biomolecules (2023)

3. Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations, International Journal of Immunopathology and Pharmacology (2019)

Experts (# of related papers)

Hossein Abdali (1)

Style	Citing Format
MLA	Palmieri A, et al.. "Rock1 Is Associated With Non-Syndromic Cleft Palate." Journal of Oral Pathology and Medicine, vol. 49, no. 2, 2020, pp. 164-168.
APA	Palmieri A, Scapoli L, Carrozzo M, Cura F, Morselli PG, Pannuto L, Nouri N, Carinci F, Lauritano D, Martinelli M (2020). Rock1 Is Associated With Non-Syndromic Cleft Palate. Journal of Oral Pathology and Medicine, 49(2), 164-168.
Chicago	Palmieri A, Scapoli L, Carrozzo M, Cura F, Morselli PG, Pannuto L, Nouri N, Carinci F, Lauritano D, Martinelli M. "Rock1 Is Associated With Non-Syndromic Cleft Palate." Journal of Oral Pathology and Medicine 49, no. 2 (2020): 164-168.
Harvard	Palmieri A et al. (2020) 'Rock1 Is Associated With Non-Syndromic Cleft Palate', Journal of Oral Pathology and Medicine, 49(2), pp. 164-168.
Vancouver	Palmieri A, Scapoli L, Carrozzo M, Cura F, Morselli PG, Pannuto L, et al.. Rock1 Is Associated With Non-Syndromic Cleft Palate. Journal of Oral Pathology and Medicine. 2020;49(2):164-168.
BibTex	@article{ author = {Palmieri A and Scapoli L and Carrozzo M and Cura F and Morselli PG and Pannuto L and Nouri N and Carinci F and Lauritano D and Martinelli M}, title = {Rock1 Is Associated With Non-Syndromic Cleft Palate}, journal = {Journal of Oral Pathology and Medicine}, volume = {49}, number = {2}, pages = {164-168}, year = {2020} }
RIS	TY - JOUR AU - Palmieri A AU - Scapoli L AU - Carrozzo M AU - Cura F AU - Morselli PG AU - Pannuto L AU - Nouri N AU - Carinci F AU - Lauritano D AU - Martinelli M TI - Rock1 Is Associated With Non-Syndromic Cleft Palate JO - Journal of Oral Pathology and Medicine VL - 49 IS - 2 SP - 164 EP - 168 PY - 2020 ER -

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