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Selective Serotonin Reuptake Inhibitors: New Hope in the Fight Against Covid-19 Publisher



Asadi Anar M1 ; Foroughi E2 ; Sohrabi E3 ; Peiravi S4 ; Tavakoli Y5 ; Kameli Khouzani M6 ; Behshood P7 ; Shamshiri M8 ; Faridzadeh A9, 10 ; Keylani K11 ; Langari SF12 ; Ansari A13 ; Khalaji A14 ; Garousi S15 Show All Authors
Authors
  1. Asadi Anar M1
  2. Foroughi E2
  3. Sohrabi E3
  4. Peiravi S4
  5. Tavakoli Y5
  6. Kameli Khouzani M6
  7. Behshood P7
  8. Shamshiri M8
  9. Faridzadeh A9, 10
  10. Keylani K11
  11. Langari SF12
  12. Ansari A13
  13. Khalaji A14
  14. Garousi S15
  15. Mottahedi M15
  16. Honari S15
  17. Deravi N1

Source: Frontiers in Pharmacology Published:2022


Abstract

The emerging COVID-19 pandemic led to a dramatic increase in global mortality and morbidity rates. As in most infections, fatal complications of coronavirus affliction are triggered by an untrammeled host inflammatory response. Cytokine storms created by high levels of interleukin and other cytokines elucidate the pathology of severe COVID-19. In this respect, repurposing drugs that are already available and might exhibit anti-inflammatory effects have received significant attention. With the in vitro and clinical investigation of several studies on the effect of antidepressants on COVID-19 prognosis, previous data suggest that selective serotonin reuptake inhibitors (SSRIs) might be the new hope for the early treatment of severely afflicted patients. SSRIs’ low cost and availability make them potentially eligible for COVID-19 repurposing. This review summarizes current achievements and literature about the connection between SSRIs administration and COVID-19 prognosis. Copyright © 2022 Asadi Anar, Foroughi, Sohrabi, Peiravi, Tavakoli, Kameli Khouzani, Behshood, Shamshiri, Faridzadeh, Keylani, Langari, Ansari, Khalaji, Garousi, Mottahedi, Honari and Deravi.
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