Design and Implementation of Interventions to Improve Sexual Health of Women With Endometriosis: A Mixed-Methods Study Protocol With an Interventional Design Publisher

Summary: Can tailored care improve sexual health in endometriosis? A new protocol plans interviews, review and a trial; effectiveness has not yet been tested. #Endometriosis #WomensHealth

Farajkhoda T ; Mohammadkhani S ; Sarebanhassanabadi M ; Zaremobini F ; Javaheri A
Source: International Journal of Reproductive BioMedicine Published:2026

Abstract

Background: Endometriosis has potential negative effects on the fertility, mental, and sexual health of women. Since the conducted studies have not comprehensively addressed the needs and strategies to improve sexual health, and to design the necessary programs and interventions for this group of women. Objective: The present study aims to design and implement interventions to improve sexual health of women with endometriosis. Materials and Methods: This sequential mixed-methods study comprises 4 phases. Phase 1 is a qualitative study using semi-structured interviews to explore needs and strategies from the perspectives of women with endometriosis and healthcare providers. Phase 2 involves a systematic review to identify additional evidence-based strategies. Phase 3 integrates findings from phases 1 and 2 with prioritization by a multidisciplinary expert panel using the Delphi technique, to develop a comprehensive intervention program. Phase 4 is a randomized controlled trial to evaluate the effectiveness of the developed intervention on sexual function and sexual quality of life compared to routine care. Conclusion: This protocol aims to develop a comprehensive, evidence-based care program integrating qualitative insights, systematic review findings, and multidisciplinary expert opinions, and to evaluate its effectiveness in improving the sexual health of women with endometriosis. © 2026, Research and Clinical Center for Infertitlity. All rights reserved.