The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats

The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats Publisher Pubmed

Amiresmaili S³ ; Shamsizadeh A³ ; Allahtavakoli M³ ; Pourshanazari AA^{2, 3} ; Roohbakhsh A^{1, 3}

Show Affiliations

1. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3. Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Source: Pharmacological Reports Published:2014

Abstract

Background: The role of transient receptor potential vanilloid 1 (TRPV1) in peripheral nervous system has been studied well but its role in the central nervous system remains to be studied in detail. The expression of TRPV1 receptors in hippocampus is suggesting that they may play an important role in higher cognitive functions such as learning and memory. Methods: In the present study, the role of TRPV1 receptors in acquisition and retrieval of spatial memory of male Wistar rats was evaluated by intra-ventral hippocampus administration of TRPV1 selective agonist (OLDA) and antagonist (AMG9810) using Morris water maze. Results: The results demonstrated that administration of either OLDA (0.001, 0.01 and 0.1 μg/rat) or AMG9810 (0.003, 0.03 and 0.3 μg/rat) did not influence memory acquisition or retrieval. Conclusions: These data suggest that ventral-hippocampal TRPV1 receptors possibly are not involved in spatial learning and memory. © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp.

2. The Effect of Rosemary Extract on Spatial Memory, Learning and Antioxidant Enzymes Activities in the Hippocampus of Middle-Aged Rats, Medical Journal of the Islamic Republic of Iran (2015)

3. Acute and Chronic Tramadol Administration Impair Spatial Memory in Rat, Research in Pharmaceutical Sciences (2016)

Experts (# of related papers)

Ali Hosseini Sharifabad (1)

Mohammad Rabbani (1)

Style	Citing Format
MLA	Amiresmaili S, et al.. "The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats." Pharmacological Reports, vol. 66, no. 1, 2014, pp. 10-14.
APA	Amiresmaili S, Shamsizadeh A, Allahtavakoli M, Pourshanazari AA, Roohbakhsh A (2014). The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats. Pharmacological Reports, 66(1), 10-14.
Chicago	Amiresmaili S, Shamsizadeh A, Allahtavakoli M, Pourshanazari AA, Roohbakhsh A. "The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats." Pharmacological Reports 66, no. 1 (2014): 10-14.
Harvard	Amiresmaili S et al. (2014) 'The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats', Pharmacological Reports, 66(1), pp. 10-14.
Vancouver	Amiresmaili S, Shamsizadeh A, Allahtavakoli M, Pourshanazari AA, Roohbakhsh A. The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats. Pharmacological Reports. 2014;66(1):10-14.
BibTex	@article{ author = {Amiresmaili S and Shamsizadeh A and Allahtavakoli M and Pourshanazari AA and Roohbakhsh A}, title = {The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats}, journal = {Pharmacological Reports}, volume = {66}, number = {1}, pages = {10-14}, year = {2014} }
RIS	TY - JOUR AU - Amiresmaili S AU - Shamsizadeh A AU - Allahtavakoli M AU - Pourshanazari AA AU - Roohbakhsh A TI - The Effect of Intra-Ventral Hippocampus Administration of Trpv1 Agonist and Antagonist on Spatial Learning and Memory in Male Rats JO - Pharmacological Reports VL - 66 IS - 1 SP - 10 EP - 14 PY - 2014 ER -

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