The Effects of Antidepressants on Neurotransmission: Translational Insights From in Vivo Electrophysiological Studies Publisher



Amidfar M¹ ; Kim YK²
Source: Neuromethods Published:2022

Abstract

Applying electrophysiological recording techniques as considerable technological progress in neurophysiological methods has provided the major advance in the neuroscience research and the study of brain–behavior relationships. This chapter presents the main electrophysiological methods currently used to study the effects of antidepressant treatments on neurotransmission. Electrophysiological studies combined with local or systemic administration of pharmacological agents will provide worthwhile strategy elucidating the pharmacological bases for reciprocal interactions of neurotransmission systems in vivo. The chapter provides authoritative review of commonly used methodologies in the field related to electrophysiological effects of antidepressant treatments on neurotransmission in the basic research level that has translational value for clinical settings. © 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.