Spastic Paraplegia With Peripheral Polyneuropathy: A Report of Three Cases



Khosrawi S^{1, 2} ; Shirzadi M¹ ; Ghadiri F¹ Show Affiliations
Source: Archives of Iranian Medicine Published:2003

Abstract

Spastic paraplegia is manifested by progressive spasticity and weakness of the legs and is one of the presenting signs of upper motor neuron disorders. Several diseases present solely with spastic gait disorders, but spastic paraplegia with severe polyneuropathy is an uncommon condition. We report three cases of spastic paraplegia from childhood with severe distal atrophy due to profound polyneuropathy; two of them had a hereditary and one sporadic (nonhereditary) background. In the present report, positive clinical and paraclinical findings with the possible differential diagnosis have been discussed.