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Genome-Wide Analysis Identifies 12 Loci Influencing Human Reproductive Behavior Publisher Pubmed



Barban N1 ; Jansen R2 ; De Vlaming R3, 4, 5 ; Vaez A6, 7 ; Mandemakers JJ8 ; Tropf FC1 ; Shen X9, 10, 11 ; Wilson JF10, 11 ; Chasman DI12 ; Nolte IM6 ; Tragante V13 ; Van Der Laan SW14 ; Perry JRB15 ; Kong A16, 17 Show All Authors
Authors
  1. Barban N1
  2. Jansen R2
  3. De Vlaming R3, 4, 5
  4. Vaez A6, 7
  5. Mandemakers JJ8
  6. Tropf FC1
  7. Shen X9, 10, 11
  8. Wilson JF10, 11
  9. Chasman DI12
  10. Nolte IM6
  11. Tragante V13
  12. Van Der Laan SW14
  13. Perry JRB15
  14. Kong A16, 17
  15. Ahluwalia TS18, 19, 20
  16. Albrecht E21
  17. Yergesarmstrong L22
  18. Atzmon G23, 24, 25
  19. Auro K26, 27
  20. Ayers K28
  21. Bakshi A29
  22. Benavraham D24
  23. Berger K30
  24. Bergman A31
  25. Bertram L32, 33
  26. Bielak LF34
  27. Bjornsdottir G16
  28. Bonder MJ35
  29. Broer L36
  30. Bui M37
  31. Barbieri C38
  32. Cavadino A39, 40
  33. Chavarro JE41, 42, 43
  34. Turman C43
  35. Concas MP44
  36. Cordell HJ28
  37. Davies G45, 46
  38. Eibich P47
  39. Eriksson N48
  40. Esko T49, 50
  41. Eriksson J51
  42. Falahi F6
  43. Felix JF4, 52, 53
  44. Fontana MA54
  45. Franke L35
  46. Gandin I55
  47. Gaskins AJ41
  48. Gieger C56, 57
  49. Gunderson EP58
  50. Guo X59
  51. Hayward C10
  52. He C60
  53. Hofer E61, 62
  54. Huang H43
  55. Joshi PK11
  56. Kanoni S63
  57. Karlsson R9
  58. Kiechl S64
  59. Kifley A65
  60. Kluttig A66
  61. Kraft P43, 67
  62. Lagou V68, 69, 70
  63. Lecoeur C71
  64. Lahti J72, 73, 74
  65. Ligao R75
  66. Lind PA76
  67. Liu T77
  68. Makalic E37
  69. Mamasoula C28
  70. Matteson L78
  71. Mbarek H79, 80
  72. Mcardle PF22
  73. Mcmahon G81
  74. Meddens SFW5, 82
  75. Mihailov E49
  76. Miller M83
  77. Missmer SA43, 84
  78. Monnereau C4, 52, 53
  79. Van Der Most PJ6
  80. Myhre R85
  81. Nalls MA86
  82. Nutile T87
  83. Kalafati IP88
  84. Porcu E89, 90
  85. Prokopenko I91, 92, 93
  86. Rajan KB94
  87. Richedwards J42, 43, 95
  88. Rietveld CA3, 4, 5
  89. Robino A96
  90. Rose LM12
  91. Rueedi R97, 98
  92. Ryan KA22
  93. Saba Y99
  94. Schmidt D37
  95. Smith JA34
  96. Stolk L36
  97. Streeten E22
  98. Tonjes A100
  99. Thorleifsson G17
  100. Ulivi S96
  101. Wedenoja J101
  102. Wellmann J30
  103. Willeit P64, 102, 103
  104. Yao J59
  105. Yengo L71, 104
  106. Zhao JH15
  107. Zhao W34
  108. Zhernakova DV35
  109. Amin N4
  110. Andrews H105
  111. Balkau B71
  112. Barzilai N23
  113. Bergmann S97, 98
  114. Biino G106
  115. Bisgaard H20
  116. Bonnelykke K20
  117. Boomsma DI79, 80
  118. Buring JE12
  119. Campbell H11
  120. Cappellani S96
  121. Ciullo M87, 107
  122. Cox SR45, 46
  123. Cucca F89, 90
  124. Toniolo D38
  125. Daveysmith G108
  126. Deary IJ45, 46
  127. Dedoussis G88
  128. Deloukas P63, 109
  129. Van Duijn CM4
  130. De Geus EJC79, 80
  131. Eriksson JG74, 110, 111, 112, 113
  132. Evans DA94
  133. Faul JD114
  134. Sala CF38
  135. Froguel P71
  136. Gasparini P55, 115
  137. Girotto G55, 115
  138. Grabe HJ116
  139. Greiser KH117
  140. Groenen PJF5, 118
  141. De Haan HG75
  142. Haerting J66
  143. Harris TB119
  144. Heath AC120
  145. Heikkila K27
  146. Hofman A4, 5, 43
  147. Homuth G121
  148. Holliday EG122, 123
  149. Hopper J37
  150. Hypponen E39, 124, 125
  151. Jacobsson B85, 126
  152. Jaddoe VWV4, 52, 53
  153. Johannesson M127
  154. Jugessur A85
  155. Kahonen M128
  156. Kajantie E129, 130, 131
  157. Kardia SLR34
  158. Keavney B28, 132
  159. Kolcic I133
  160. Koponen P134
  161. Kovacs P135
  162. Kronenberg F136
  163. Kutalik Z98, 137
  164. La Bianca M96
  165. Lachance G138
  166. Iacono WG83
  167. Lai S89
  168. Lehtimaki T139
  169. Liewald DC45
  170. Lindgren CM92, 93, 140, 141
  171. Liu Y142
  172. Luben R143
  173. Lucht M110
  174. Luoto R144
  175. Magnus P85
  176. Magnusson P9
  177. Martin NG76
  178. Mcgue M83, 145
  179. Mcquillan R11
  180. Medland SE76
  181. Meisinger C57, 146
  182. Mellstrom D51
  183. Metspalu A49, 147
  184. Traglia M38
  185. Milani L49
  186. Mitchell P65
  187. Montgomery GW120, 148
  188. Mookkanamori D75, 149, 150
  189. De Mutsert R75
  190. Nohr EA151
  191. Ohlsson C51
  192. Olsen J152
  193. Ong KK15
  194. Paternoster L108
  195. Pattie A46
  196. Penninx BWJH2, 80
  197. Perola M26, 27, 49
  198. Peyser PA34
  199. Pirastu M44
  200. Polasek O133
  201. Power C39
  202. Kaprio J26, 27, 101
  203. Raffel LJ153
  204. Raikkonen K72
  205. Raitakari O154
  206. Ridker PM12
  207. Ring SM108
  208. Roll K59
  209. Rudan I11
  210. Ruggiero D87
  211. Rujescu D155
  212. Salomaa V26
  213. Schlessinger D156
  214. Schmidt H99
  215. Schmidt R61
  216. Schupf N157
  217. Smit J2, 80
  218. Sorice R87, 107
  219. Spector TD138
  220. Starr JM45, 158
  221. Stockl D157
  222. Strauch K21, 159
  223. Stumvoll M100, 135
  224. Swertz MA35
  225. Thorsteinsdottir U17, 160
  226. Roy Thurik A3, 5, 161
  227. Timpson NJ108
  228. Tung JY48
  229. Uitterlinden AG3, 5, 36
  230. Vaccargiu S44
  231. Viikari J162
  232. Vitart V10
  233. Volzke H163
  234. Vollenweider P164
  235. Vuckovic D55, 115
  236. Waage J20
  237. Wagner GG165
  238. Wang JJ65
  239. Wareham NJ15
  240. Weir DR114
  241. Willemsen G79, 80
  242. Willeit J64
  243. Wright AF10
  244. Zondervan KT166, 167
  245. Stefansson K17, 160
  246. Krueger RF83
  247. Lee JJ83
  248. Benjamin DJ54, 168
  249. Cesarini D169, 170
  250. Koellinger PD3, 5, 82
  251. Den Hoed M171
  252. Snieder H6
  253. Mills MC1

Source: Nature Genetics Published:2016


Abstract

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
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