The Effect of Epstein-Barr Virus Latent Membrane Protein-1 Status on Outcome of Patients With Classic Hodgkin's Lymphoma



Rajabi MA¹ ; Rajabi P¹ ; Eftekhari A¹ ; Eftekhari M¹ ; Ghasemibasir HR¹ ; Mesbah AR¹ Show Affiliations
Source: Pakistan Journal of Medical Sciences Published:2008

Abstract

Objective: This study determines the expression of latent membrane protein-1(LMP-1) in lymph nodes of patients with classic Hodgkin lymphoma (cHL) and its role in patients' survival. Methodology: Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival (DFS) was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1in outcome of patients with cHL. Results: LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight (25.5%) patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% (P= 0.005). Patients with EBV-positive tumors had fewer DFS (22.6 vs. 25.9 mo), but the difference was not statistically significant (p=0.06). Conclusion: Although in our study there is no relationship between age and LMP-1expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL.