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Harnessing Crispr/Cas9 Technology in Cardiovascular Disease Publisher Pubmed



Rezaei H1 ; Khadempar S2 ; Farahani N3 ; Hosseingholi EZ4 ; Hayat SMG2 ; Sathyapalan T5 ; Sahebkar AH6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Departeman of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
  3. 3. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology, Faculty of basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
  5. 5. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, HU3 2JZ, United Kingdom
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Trends in Cardiovascular Medicine Published:2020


Abstract

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes. The CRISPR/Cas9 system also potentially has the ability to prevent and treat human diseases. The present article addresses some key points related to the use of the CRISPR/Cas9 system as a powerful tool in cardiovascular research and as a new strategy for the treatment of cardiovascular disease (CVD). © 2019 Elsevier Inc.
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