Inflammation-Related Microrna Alterations in Epilepsy: A Systematic Review of Human and Animal Studies Publisher



Mj Yousefi Mohammad JAVAD ; A Rezvanimehr ALI ; K Saleki KIARASH ; A Mehrani AIDA ; E Barootchi ERFAN ; M Ramezankhah MOHAMMAD ; A Mazloomi A ; As Nateri Abdolrahman SHAMS ; S Barootchi SHAYAN ; N Rezaei NIMA
Source: Reviews in the Neurosciences Published:2025

Abstract

Epilepsy is a neurological condition that affects around 50 million people globally. While the underlying mechanism of epilepsy is not fully understood, emerging evidence demonstrates that inflammation is a key player in the pathogenesis of epilepsy. MicroRNAs are involved in the pathogenesis of epilepsy, particularly through regulating oxidative stress, apoptosis, and inflammation. In this systematic review, we analyzed and summarized data from the literature regarding the role of inflammatory miRNAs in the pathophysiology of epilepsy, through human and animal studies. Twenty one reports on humans and 44 reports on animals were included in the current analysis. Kainic acid (KA) and pilocarpine were broadly used approaches in inducing epilepsy in animal models. Among upregulated microRNAs, miR-146a, miR-155, and miR-132 were more emphasized for their inflammatory role involved in epilepsy. MiR-221, miR-222, and miR-29a were downregulated and were associated with anti-inflammatory effects. Notably, microRNAs demonstrated tissue-specific expression patterns in different samples, including brain cortex, hippocampus, and body fluids, which is considerable in further investigations in the pathophysiologic and diagnostic roles of inflammatory microRNAs in epilepsy. Furthermore, inflammatory miRNAs regulate critical signaling pathways like TLR4/NF-κB, PI3K/Akt, anda€‚IL-1β-mediated neuroinflammation. Conclusively, these findings highlight the possibility of using inflammatory miRNAs as diagnostic biomarkers and therapeutic targets of epilepsies. © 2025 Elsevier B.V., All rights reserved.