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Comparative Analysis of Treatment Options for Chronic Heart Failure and Depression: A Systematic Review and Bayesian Network Meta-Analysis Publisher Pubmed

Summary: Meta-analysis finds cognitive behavioral therapy most effective for depression in heart failure patients. #HeartFailure #Depression

Soleimani H1, 2, 3 ; Nasrollahizadeh A1, 4 ; Hajiqasemi M1, 5 ; Ebrahimzade M1, 5 ; Taheri H6 ; Ebrahimi P1 ; Ashraf H2 ; Samsky MD7 ; Hosseini K1, 2
Authors

Source: Heart Failure Reviews Published:2024


Abstract

Different interventions have been evaluated for the treatment of depression in heart failure (HF) patients. However, clear and established recommendations are lacking. PubMed, Scopus, and Web of Science databases were systematically searched for randomized controlled trials (RCT) evaluating the effect of various treatment options on depression scores in heart failure patients. The primary outcome was a change in depression scores presented as standardized mean difference (SMD). A Bayesian network for meta-analysis was constructed. Twenty-five RCTs were included, randomizing 6014 patients with confirmed heart failure and depression between 2003 and 2022. Compared to treatment as usual (TAU), only cognitive behavioral therapy (CBT) (SMD − 0.60, CI95% [− 1.0, − 0.17]) leads to a significant reduction in depression scores. Other interventions did not improve depression scores significantly. Our results show that for patients with HF and depression, CBT can significantly improve measures of depression, being the most efficacious treatment. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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