Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Antibody Titer in Iranian Children 6 Years After Hepatitis B Vaccine Administration Publisher Pubmed



Hassan S1 ; Ziba F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Medical University, Iran

Source: Vaccine Published:2007


Abstract

Objective: The purpose of study was to evaluate the immune response in a sample of vaccinated children aged 6 years. Background: Although immunization of infants against hepatitis B virus (HBV) is the most effective way to prevent infection, duration of the afforded immunization is unknown. Methods: The immunity derived from the HBV vaccine was assessed by measuring the antibody in 3752 children who were vaccinated in a routine vaccination program in three cities of Iran (Isfahan, Khoramabad, Shahrekord). Results: Seven hundred and twenty-three (19.3%) children had antibodies levels <10 MIU/mL and 1096 (29.2%) had antibodies levels ≥100 MIU/mL. The total GMT was 34.5 ± 0.66, and GMT was statistically different in non-immune and immune children (3.1 ± 0.36 versus 49.1 ± 0.52). No correlation was found between HbsAb titers and growth pattern during the first and sixth years of life, number of vaccine, time of vaccination and drug use. The predictors were low birth weight and chronic disease. Conclusion: It is recommended that high risk children should be monitored regularly for anti-HBS, and booster must be administrated, if necessary. © 2005 Elsevier Ltd. All rights reserved.
Related Docs
View other Related Docs
1. Effectiveness of Hepatitis B Vaccination in Children of Chronic Hepatitis B Mothers, Saudi Medical Journal (2004)
2. Efficacy of Double Dose Recombinant Hepatitis B Vaccination in Chronic Hepatitis C Patients, Compared to Standard Dose Vaccination, International Journal of Preventive Medicine (2014)
3. Seroprevalence of Hepatitis B Virus Infection and Hepatitis B Surface Antibody Status Among Laboratory Health Care Workers in Isfahan, Iran, Asian Journal of Transfusion Science (2015)
4. Comparing the Effectiveness of a Short-Term Double-Dose Hepatitis B Vaccination Schedule With the Standard 3-Dose Schedule: A Randomized Clinical Trial, Tehran University Medical Journal (2011)
5. Effect of Tetanus-Diphtheria (Td) Vaccine on Immune Response to Hepatitis B Vaccine in Healthy Individuals With Insufficient Immune Response, Journal of Research in Medical Sciences (2015)
6. Seroprevalence of Hepatitis a in Iranian Adolescents: Is It Time to Introduce a Vaccine?, Epidemiology and Infection (2016)
7. Seroprevalence of Bordetella Pertussis Among a Nationally Representative Sample of Iranian Pediatric Population: The Childhood and Adolescence Surveillance and Prevention of Adult Noncommunicable Disease-V Study, Journal of Research in Medical Sciences (2021)
8. Hepatitis B Markers in Isfahan, Central Iran: A Population-Based Study, Hepatitis Monthly (2009)
Experts (# of related papers)
View all Related Experts
Behrooz Ataei (23)
Zary Nokhodian (12)
Other Related Docs
9. A Cross-Sectional Study on the Reasons for Vaccine Hesitancy in Children Under Seven Years of Age in Isfahan, Iran, Vaccine: X (2023)
10. Effect of Tetanus-Diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-Responder Individuals, International Journal of Preventive Medicine (2016)
11. Comparison of Hbs-Antibody Serum Levels Between Patients With Type 2 Diabetes Mellitus and Controls Following Vaccination Against Hepatitis B, Journal of Isfahan Medical School (2007)
12. Hepatitis D Virus Infection in Isfahan, Central Iran: Prevalence and Risk Factors Among Chronic Hbv Infection Cases, Hepatitis Monthly (2011)
13. Acute Adverse Events Following Immunization With Dtp-Hb-Hib Pentavalent Vaccine in the First Year of Life; [Manifestations Postvaccinales Indesirables Aigues Liees Au Vaccin Pentavalent Dtchb-Hib Au Cours De La Premiere Annee De Vie], Eastern Mediterranean Health Journal (2023)
14. Occult Hepatitis B Virus Infection Among Human Immunodeficiency Virus-Infected Patients With Isolated Hepatitis B Core Antibody in Isfahan, Iran, Journal of Research in Medical Sciences (2014)
15. Hepatitis G Virus Exposure in Dialysis Patients and Blood Donors in Isfahan-Iran, International Journal of Preventive Medicine (2014)
16. Disseminated Bacille Calmette-Guerin Vaccine-Induced Disease in a Sample of Iranian Children: A Longitudinal Case-Series Study, Archives of Pediatric Infectious Diseases (2025)
17. Immunogenicity and Safety of Three Who Prequalified (Dtwp -Hb-Hib) Pentavalent Combination Vaccines Administered As Per Iranian National Immunization Plan in Iranian Infants: A Randomized, Phase Iii Study, Indian Pediatrics (2021)
18. Attitudes Towards Maternal Screening for Hepatitis B Virus Infection in Iran., Tropical gastroenterology : official journal of the Digestive Diseases Foundation (2010)
19. Timing and Delay in Children Vaccination; Evaluation of Expanded Program of Immunization in Outskirt of Iranian Cities, Journal of Research in Health Sciences (2015)
20. A Case-Control Study of Risk Factors for Hepatitis B Infection: A Regional Report Among Isfahanian Adults, Journal of Research in Medical Sciences (2019)
21. Occult Hepatitis B Virus Infection Among Blood Donors With Antibodies to Hepatitis B Core Antigen, Acta Medica Iranica (2008)
22. Should We Consider Another Booster Dose of Measles Vaccine?, Iranian Journal of Medical Sciences (2002)
23. Comparison of the Prevalence and Risk Factors of Hepatitis a in 10 to 18-Year-Old Adolescents of Sixteen Iranian Provinces: The Caspian-Iii Study, Hepatitis Monthly (2016)
24. Importance of the Covid-19 Vaccine Booster Dose in Protection and Immunity, Vaccines (2022)
25. Hepatitis B Virus Surface Antigen Variants Clustered Within Immune Epitopes in Chronic Hepatitis B Carriers From Hormozgan Province, South of Iran, Iranian Journal of Basic Medical Sciences (2010)
26. Seroprevalence of Hepatitis a Among Street Children, Isfahan, Iran, Journal of Isfahan Medical School (2012)
27. Evaluation of Anti-Sars-Cov-2 Rbd Antibody Response After Booster Dose of Spikogen® in Individuals With Two Previous Doses of Sinopharm and Its Association With Hla-Dr and -Dq Alleles, Human Immunology (2025)
28. Hepatitis B and C Among Patients Infected With Human Immunodeficiency Virus in Isfahan, Iran: Seroprevalence and Associated Factors, Hepatitis Monthly (2010)
29. Seroepidemiology of Hepatitis a Virus Infections in Over 6-Years Population in Isfahan–Iran: A Community-Based Study, Journal of Isfahan Medical School (2007)
30. Seroprevalence of Hepatitis a Virus in Patients With Chronic Hepatitis B or C in Isfahan Province, Iran, Journal of Isfahan Medical School (2012)
31. Protective Status of End-Stage Renal Disease Children Against Tetanus and Diphtheria Vaccination, International Journal of Preventive Medicine (2013)
32. Prevalence of Hepatitis B Virus Infection in Isfahan Province, International Journal of Preventive Medicine (2014)
33. Efficacy and Safety of an Inactivated Virus-Particle Vaccine for Sars-Cov-2, Biv1-Coviran: Randomised, Placebo Controlled, Double Blind, Multicentre, Phase 3 Clinical Trial, BMJ (2023)
34. Lamivudine's Efficacy and Safety in Preventing Mother-Tochild Transmission of Hepatitis B: A Meta-Analysis, Turkish Journal of Gastroenterology (2019)
35. Response Rate to Hepatitis B Vaccination in Patients With Chronic Renal Failure and End-Stage-Renal-Disease: Influence of Diabetes Mellitus, Journal of Research in Medical Sciences (2005)
36. Hepatitis a Seropositivity Among Newly Admitted Medical Students of Isfahan, Kermanshah, and Hamedan: A Seroprevalence Study, Journal of Research in Medical Sciences (2014)
37. Construction and Evaluation of Dna Vaccine Encoding Fusion Protein of Hepatitis C Virus Core Protein and Hepatitis B Surface Antigen As a Vaccine Candidate, Journal of Isfahan Medical School (2013)
38. Seroepidemiology of Bordetella Pertussis Infection in Fresh College Students in Iran: A Multicenter Study, Archives of Clinical Infectious Diseases (2014)
39. How Much Does Vaccination Reduce the Rate of Hbv Infection in Iranian Population? a Bayesian Adjustment Analysis, Gastroenterology and Hepatology from Bed to Bench (2019)
40. Hepatitis B Virus Genotype, Hbsag Mutations and Co-Infection With Hcv in Occult Hbv Infection, Clinics and Research in Hepatology and Gastroenterology (2011)
41. A Nationwide Study on the Seroprevalence of Measles, Mumps, and Rubella in Iranian Children and Adolescents, Iranian Journal of Public Health (2022)
42. Hepatitis B Virus Genotype D Is the Only Genotype Circulating in Iranian Chronic Carriers, the Unique Pattern of Genotypic Homogeneity, Journal of Gastroenterology and Hepatology Research (2014)
43. Immunogenicity and Efficacy of Hoshino Strain of Mumps Vaccine in Iran; Two Years Study., East African journal of public health (2011)
44. Comparative Study of the Level of Neutralizing Antibodies in People Injecting 4 Types of Covid-19 Vaccine; [بررسیمقایسهایسطح آنتیبادیخنثیکنندهدر افراد تزریقکنندهی4نوع واکسن کووید-], Journal of Isfahan Medical School (2024)
45. Seroprevalence of Hepatitis a in Patients With Chronic Hepatitis C in Isfahan Province, International Journal of Preventive Medicine (2012)
46. The Assessment of Hepatitis B Seroprevalence in Persons With Intravenous Drug Use History in the Isfahan Province: Community-Based Study, Journal of Research in Medical Sciences (2014)
47. Hepatitis a Seropositivity Among First-Year Students of the Medical University in Isfahan, Iran, International Journal of Preventive Medicine (2014)
48. Seroprevalence of Hepatitis B Infection and Associated Risk Factors Among Drug Users in Drop-In Centers of Isfahan, Iran, International Journal of Preventive Medicine (2018)
49. Seroprevalence of Mumps Before Inclusion of Mumps Vaccination in the Iranian Expanded Programme on Immunization, Eastern Mediterranean Health Journal (2009)
50. Hav in Isfahan Province: A Population-Based Study., Tropical gastroenterology : official journal of the Digestive Diseases Foundation (2008)