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New Myrsinane-Type Diterpenoids From Euphorbia Aellenii Rech. F. With Their Immunomodulatory Activity Publisher Pubmed



Ayatollahi AM1 ; Ghanadian M2 ; Mesaik MA3 ; Mohamed Abdella O3 ; Afsharypuor S4 ; Kobarfard F5 ; Mirzataheri M1
Authors
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Authors Affiliations
  1. 1. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
  4. 4. Isfahan Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Asian Natural Products Research Published:2010


Abstract

Two new 14-desoxo-10, 18-dihydromyrinsol diterpenoids (1 and 2) were isolated and characterized from the cytotoxic chloroform fraction of Euphorbia aellenii Rech. f. (Euphorbiaceae). The structures of the new compounds were elucidated by spectroscopic methods and their immunomodulatory properties were evaluated by T-cell proliferation and phagocyte chemiluminescence assays. © 2010 Taylor & Francis.
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