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Non-Rigid Registration of Fluorescein Angiography and Optical Coherence Tomography Via Scanning Laser Ophthalmoscope Imaging Publisher Pubmed



Ghasemi Kamasi Z1 ; Mokhtari M2 ; Rabbani H2
Authors
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Authors Affiliations
  1. 1. Department of Computer Science and Electrical Engineering, WVU, 26505, United States
  2. 2. Department of Biomedical Engineering, Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS Published:2017


Abstract

Fluorescein Angiography (FA) imaging is the gold standard technique for neurovascular imaging regarding assessing neurovascular diseases such as Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME). On the other hand, as FA imaging is invasive and does not provide any depth information, Optical Coherence Tomography (OCT) imaging technique is a good complementary for it in diagnosis process. To correlate the information of both FA and OCT images, an image alignment/registration process is needed. In absence of an automatic registration software, the clinician should do intuitive comparison to integrate these data which is a subjective and time consuming process. In this paper, we demonstrate a non-rigid registration method called multi-step correlation-based registration algorithm to automatically register FA and OCT images together. Our algorithm consists of two steps including rigid/global and non-rigid/local registration. We evaluate our algorithm's performance by labeling Micro-Aneurysm (MA) spots -hallmarks of DR- on FA images and determining MA regions on OCT B-scans after registration. Our Results show that our algorithm performs accurately regarding registration of FA images and OCT B-scans. © 2017 IEEE.
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