Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing

Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing Publisher Pubmed

Chavezmadero C^{1, 2, 3} ; De Leonderby MD^{1, 2} ; Samandari M⁴ ; Ceballosgonzalez CF^{1, 5} ; Bolivarmonsalve EJ^{1, 5} ; Mendozabuenrostro C^{6, 7} ; Holmberg S^{2, 8} ; Garzaflores NA^{1, 5} ; Almajhadi MA⁹ ; Gonzalezgamboa I^{1, 5} ; Yeede Leon JF¹⁰ ; Martinezchapa SO² ; Rodriguez CA^{6, 7} ; Wickramasinghe HK^{2, 9} Show All Authors

Chavezmadero C^{1, 2, 3}
De Leonderby MD^{1, 2}
Samandari M⁴
Ceballosgonzalez CF^{1, 5}
Bolivarmonsalve EJ^{1, 5}
Mendozabuenrostro C^{6, 7}
Holmberg S^{2, 8}
Garzaflores NA^{1, 5}
Almajhadi MA⁹
Gonzalezgamboa I^{1, 5}
Yeede Leon JF¹⁰
Martinezchapa SO²
Rodriguez CA^{6, 7}
Wickramasinghe HK^{2, 9}
Madou M^{2, 8}
Dean D¹¹
Khademhosseini A^{12, 13, 14, 15}
Zhang YS^{3, 16}
Alvarez MM^{1, 5, 16, 17}
Trujillode Santiago G^{1, 2, 16, 17}

Show Affiliations

1. Centro de Biotecnologia-FEMSA, Tecnologico de Monterrey, NL, Monterrey, 64849, Mexico
2. Departamento de Ingenieria Mecatronica y Electrica, Escuela de Ingenieria y Ciencias Tecnologico de Monterrey, NL, Monterrey, 64849, Mexico
3. Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, MA, United States
4. Department of Physiology, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
5. Departamento de Bioingenieria, Escuela de Ingenieria y Ciencias, Tecnologico de Monterrey, NL, Monterrey, 64849, Mexico
6. Departamento de Ingenieria Mecanica y Materiales Avanzados, Escuela de Ingenieria y Ciencias, Tecnologico de Monterrey, NL, Monterrey, 64849, Mexico
7. Laboratorio Nacional de Manufactura Aditiva y Digital, Apodaca NL, 66629, Mexico
8. Department of Mechanical and Aerospace Engineering, University of California, Irvine, 92697, CA, United States
9. Department of Electrical Engineering and Computer Sciences, University of California, Irvine, 92697, CA, United States
10. Delee Corp., Mountain View, 94041, CA, United States
11. Department of Plastic and Reconstructive Surgery, Ohio State University, Columbus, 43210, OH, United States
12. Department of Bioengineering. Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, United States
13. Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, United States
14. Terasaki Institute for Biomedical Innovation, Los Angeles, 90049, CA, United States
15. California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA, United States
16. Harvard-MIT Division of Health Sciences and Technology, Cambridge, 02139, MA, United States
17. Microsystems Technologies Laboratories, Mit, Cambridge, 02139, MA, United States

Source: Biofabrication Published:2020

Abstract

This paper introduces the concept of continuous chaotic printing, i.e. the use of chaotic flows for deterministic and continuous extrusion of fibers with internal multilayered micro-or nanostructures. Two free-flowing materials are coextruded through a printhead containing a miniaturized Kenics static mixer (KSM) composed of multiple helicoidal elements. This produces a fiber with a well-defined internal multilayer microarchitecture at high-throughput (>1.0 m min-1). The number of mixing elements and the printhead diameter determine the number and thickness of the internal lamellae, which are generated according to successive bifurcations that yield a vast amount of inter-material surface area (∼102 cm2 cm-3) at high resolution (∼10 µm). This creates structures with extremely high surface area to volume ratio (SAV). Comparison of experimental and computational results demonstrates that continuous chaotic 3D printing is a robust process with predictable output. In an exciting new development, we demonstrate a method for scaling down these microstructures by 3 orders of magnitude, to the nanoscale level (∼150 nm), by feeding the output of a continuous chaotic 3D printhead into an electrospinner. The simplicity and high resolution of continuous chaotic printing strongly supports its potential use in novel applications, including-but not limited to-bioprinting of multi-scale layered biological structures such as bacterial communities, living tissues composed of organized multiple mammalian cell types, and fabrication of smart multi-material and multilayered constructs for biomedical applications. © 2020 The Author(s). Published by IOP Publishing Ltd.

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Style	Citing Format
MLA	Chavezmadero C, et al.. "Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing." Biofabrication, vol. 12, no. 3, 2020, pp. -.
APA	Chavezmadero C, De Leonderby MD, Samandari M, Ceballosgonzalez CF, Bolivarmonsalve EJ, Mendozabuenrostro C, Holmberg S, Garzaflores NA, Almajhadi MA, Gonzalezgamboa I, Yeede Leon JF, Martinezchapa SO, Rodriguez CA, Wickramasinghe HK, Madou M, Dean D, Khademhosseini A, Zhang YS, Alvarez MM, Trujillode Santiago G (2020). Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing. Biofabrication, 12(3), -.
Chicago	Chavezmadero C, De Leonderby MD, Samandari M, Ceballosgonzalez CF, Bolivarmonsalve EJ, Mendozabuenrostro C, Holmberg S, et al.. "Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing." Biofabrication 12, no. 3 (2020): -.
Harvard	Chavezmadero C et al. (2020) 'Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing', Biofabrication, 12(3), pp. -.
Vancouver	Chavezmadero C, De Leonderby MD, Samandari M, Ceballosgonzalez CF, Bolivarmonsalve EJ, Mendozabuenrostro C, et al.. Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing. Biofabrication. 2020;12(3):-.
BibTex	@article{ author = {Chavezmadero C and De Leonderby MD and Samandari M and Ceballosgonzalez CF and Bolivarmonsalve EJ and Mendozabuenrostro C and Holmberg S and Garzaflores NA and Almajhadi MA and Gonzalezgamboa I and Yeede Leon JF and Martinezchapa SO and Rodriguez CA and Wickramasinghe HK and Madou M and Dean D and Khademhosseini A and Zhang YS and Alvarez MM and Trujillode Santiago G}, title = {Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing}, journal = {Biofabrication}, volume = {12}, number = {3}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Chavezmadero C AU - De Leonderby MD AU - Samandari M AU - Ceballosgonzalez CF AU - Bolivarmonsalve EJ AU - Mendozabuenrostro C AU - Holmberg S AU - Garzaflores NA AU - Almajhadi MA AU - Gonzalezgamboa I AU - Yeede Leon JF AU - Martinezchapa SO AU - Rodriguez CA AU - Wickramasinghe HK AU - Madou M AU - Dean D AU - Khademhosseini A AU - Zhang YS AU - Alvarez MM AU - Trujillode Santiago G TI - Using Chaotic Advection for Facile High-Throughput Fabrication of Ordered Multilayer Micro-And Nanostructures: Continuous Chaotic Printing JO - Biofabrication VL - 12 IS - 3 SP - EP - PY - 2020 ER -

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