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Hepatoprotective Effect of Chichorium Intybus L. on Liver Toxicity in Rat



Madani H1 ; Asgary S2 ; Naderi GH2 ; Talebolhoseini M1
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Iran

Source: Journal of Medicinal Plants Published:2006

Abstract

Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent hepatoprotective effects. Objective: In this study, we have investigated the protective effects of polyphenolic extracts of Silybum marianum and Chichorium intybus on thioacethamide-induced hepatotoxicity in rat. Methods: Extracts were injected to rats, at a dose of 25 mg/kg body weight together with thioacetamide at a dose of 50 mg/kg body weight. For investigation of the hepatoprotective effect of extracts against thioacetamide, activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilyrubin, Na+ and K+ were measured. Results: significant decreases were observed in activities of aminotransferases, alkalin phosphatase and bilyrubin in groups that treated with extracts together with thioacetamide in comparation with thioacetamide treated group. Level of Na+,K+ and liver weight betwen different groups had not significant different. Conclusions: This results showed protective effect of chichorium extracts on thioacetamide-induced hepatotoxicity in rat.
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