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Nrf-Mediated Autophagy and Upr: Exploring New Avenues to Overcome Cancer Chemo-Resistance Publisher Pubmed

Summary: Study suggests targeting NRF pathways to overcome cancer chemoresistance via autophagy and UPR. #CancerTherapy #Chemoresistance

Dastghaib S1 ; Shafiee SM2 ; Ramezani F3 ; Ashtari N4 ; Tabasi F5 ; Saffarichaleshtori J6, 7 ; Siri M8 ; Vakili O8, 9 ; Igder S10 ; Zamani M8 ; Niknam M2 ; Nasery MM11 ; Kokabi F12 ; Wiechec E13, 14, 17 Show All Authors
Authors
  1. Dastghaib S1
  2. Shafiee SM2
  3. Ramezani F3
  4. Ashtari N4
  5. Tabasi F5
  6. Saffarichaleshtori J6, 7
  7. Siri M8
  8. Vakili O8, 9
  9. Igder S10
  10. Zamani M8
  11. Niknam M2
  12. Nasery MM11
  13. Kokabi F12
  14. Wiechec E13, 14, 17
  15. Mostafavipour Z6, 8
  16. Mokarram P2
  17. Ghavami S4, 14, 15, 16

Source: European Journal of Pharmacology Published:2025


Abstract

The development of chemo-resistance remains a significant hurdle in effective cancer therapy. NRF1 and NRF2, key regulators of redox homeostasis, play crucial roles in the cellular response to oxidative stress, with implications for both tumor growth and resistance to chemotherapy. This study delves into the dualistic role of NRF2, exploring its protective functions in normal cells and its paradoxical support of tumor survival and drug resistance in cancerous cells. We investigate the interplay between the PERK/NRF signaling pathway, ER stress, autophagy, and the unfolded protein response, offering a mechanistic perspective on how these processes contribute to chemoresistance. Our findings suggest that targeting NRF signaling pathways may offer new avenues for overcoming resistance to chemotherapeutic agents, highlighting the importance of a nuanced approach to redox regulation in cancer treatment. This research provides a molecular basis for the development of NRF-targeted therapies, potentially enhancing the efficacy of existing cancer treatments and offering hope for more effective management of resistant tumors. © 2024 The Authors
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