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Metal-Organic Frameworks: A Promising Option for the Diagnosis and Treatment of Alzheimer's Disease Publisher Pubmed



Tajahmadi S1 ; Molavi H2, 3 ; Ahmadijokani F4 ; Shamloo A1, 5, 6 ; Shojaei A1, 2 ; Sharifzadeh M7 ; Rezakazemi M8 ; Fatehizadeh A9, 10 ; Aminabhavi TM11, 12 ; Arjmand M4
Authors
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Authors Affiliations
  1. 1. Institute for Nanoscience and Nanotechnology (INST), Sharif University of Technology, Tehran, Iran
  2. 2. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  3. 3. Department of Chemistry, Institute for Advanced Studies in Basic Science (IASBS), Gava Zang, Zanjan, 45137-66731, Iran
  4. 4. Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, V1V 1V7, BC, Canada
  5. 5. Department of Mechanical Engineering, Sharif University of Technology, Azadi Ave, Tehran, Iran
  6. 6. Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, 11155-9161, Iran
  7. 7. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Iran
  9. 9. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. School of Advanced Sciences, KLE Technological University, Karnataka, Hubballi, 580 031, India
  12. 12. School of Engineering, UPES, Bidholi, Uttarakhand, Dehradun, 248 007, India

Source: Journal of Controlled Release Published:2023


Abstract

Beta-amyloid (Aβ) peptide is one of the main characteristic biomarkers of Alzheimer's disease (AD). Previous clinical investigations have proposed that unusual concentrations of this biomarker in cerebrospinal fluid, blood, and brain tissue are closely associated with the AD progression. Therefore, the critical point of early diagnosis, prevention, and treatment of AD is to monitor the levels of Aβ. In view of the potential of metal-organic frameworks (MOFs) for diagnosing and treating the AD, much attention has been focused in recent years. This review discusses the latest advances in the applications of MOFs for the early diagnosis of AD via fluorescence and electrochemiluminescence (ECL) detection of AD biomarkers, fluorescence detection of the main metal ions in the brain (Zn2+, Cu2+, Mn2+, Fe3+, and Al3+) in addition to magnetic resonance imaging (MRI) of the Aβ plaques. The current challenges and future strategies for translating the in vitro applications of MOFs into in vivo diagnosis of the AD are discussed. © 2022
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