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Does Dietary Intake of Vitamin a and Beta-Carotene Increase the Risk of Hypertension? Publisher



Rahmanian S1 ; Salimi Z2 ; Masoumvand M3 ; Aghakhani Nejad Z4 ; Ghorbani Hesari M5 ; Mirshafaei SR6 ; Keshavarz Mohammadian M7 ; Abbasi Mobarakeh K8 ; Ataei Kachooei M9 ; Shamsigoushki A10 ; Khoshdooz S11 ; Bahmani P12 ; Doaei S12, 13 ; Kooshki A14 Show All Authors
Authors
  1. Rahmanian S1
  2. Salimi Z2
  3. Masoumvand M3
  4. Aghakhani Nejad Z4
  5. Ghorbani Hesari M5
  6. Mirshafaei SR6
  7. Keshavarz Mohammadian M7
  8. Abbasi Mobarakeh K8
  9. Ataei Kachooei M9
  10. Shamsigoushki A10
  11. Khoshdooz S11
  12. Bahmani P12
  13. Doaei S12, 13
  14. Kooshki A14
  15. Gholamalizadeh M15

Source: Cardiovascular Endocrinology and Metabolism Published:2024


Abstract

Background Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A. Methods This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire. Result A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, P=0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, P=0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN. Conclusion Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. Further longitudinal studies are needed to confirm these findings and elucidate the underlying mechanisms. Copyright © 2024 The Author(s).
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