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Does Dietary Intake of Vitamin a and Beta-Carotene Increase the Risk of Hypertension? Publisher



Rahmanian S1 ; Salimi Z2 ; Masoumvand M3 ; Aghakhani Nejad Z4 ; Ghorbani Hesari M5 ; Mirshafaei SR6 ; Keshavarz Mohammadian M7 ; Abbasi Mobarakeh K8 ; Ataei Kachooei M9 ; Shamsigoushki A10 ; Khoshdooz S11 ; Bahmani P12 ; Doaei S12, 13 ; Kooshki A14 Show All Authors
Authors
  1. Rahmanian S1
  2. Salimi Z2
  3. Masoumvand M3
  4. Aghakhani Nejad Z4
  5. Ghorbani Hesari M5
  6. Mirshafaei SR6
  7. Keshavarz Mohammadian M7
  8. Abbasi Mobarakeh K8
  9. Ataei Kachooei M9
  10. Shamsigoushki A10
  11. Khoshdooz S11
  12. Bahmani P12
  13. Doaei S12, 13
  14. Kooshki A14
  15. Gholamalizadeh M15
Show Affiliations
Authors Affiliations
  1. 1. Nursing Faculty, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Department of Applied Mathematics, Roudsar and Amlash Branch, Islamic Azad University, Rudsar, Iran
  7. 7. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  8. 8. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran
  9. 9. Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  10. 10. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Department of Obstetrics and Gynecology, Reproductive Health Research Center, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  14. 14. Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  15. 15. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Cardiovascular Endocrinology and Metabolism Published:2024


Abstract

Background Hypertension (HTN) is a major global public health issue influenced by genetics and lifestyle factors such as diet and psychological stress. Previous research suggests a potential link between HTN and dietary vitamin A intake. This study aims to explore the association between HTN and the intake of various forms of vitamin A. Methods This cross-sectional study was conducted on 1239 patients with HTN and 2945 normotensive individuals aged 35-70 years in Sabzevar, Iran. Dietary vitamin A intake was assessed using the Nutritionist IV software and a food frequency questionnaire. Result A positive association was found between HTN with total vitamin A intake [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.01-1.05, P=0.04] and β-carotene intake (OR: 1.03, 95% CI: 1.02-1.05, P=0.03) after adjusting for age and sex. These associations remained statistically significant after adjusting for physical activity and BMI. The association between HTN and β-carotene intake remained significant after additional adjustment for calorie intake. No significant association was observed between dietary retinol intake and HTN. Conclusion Increased dietary intake of vitamin A and β-carotene may be associated with a higher risk of HTN. Further longitudinal studies are needed to confirm these findings and elucidate the underlying mechanisms. Copyright © 2024 The Author(s).
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