Effects of Zinc Supplementation During Pregnancy on Pregnancy Outcome in Women With History of Preterm Delivery: A Double-Blind Randomized, Placebo-Controlled Trial Publisher Pubmed



Danesh A¹ ; Janghorbani M² ; Mohammadi B¹
Source: Journal of Maternal-Fetal and Neonatal Medicine Published:2010

Abstract

Objectives. The aim of this study was to assess the effect of high dose zinc (Zn) supplement during pregnancy in pregnancy outcome in healthy pregnant women with a previous preterm delivery in Isfahan, Iran. Methods. A double-blind placebo-controlled randomized clinical trial was conducted between January 2007 and June 2008. Eighty-four pregnant women with a previous preterm delivery age 19 to 35 years were randomly allocated to receive either 50mg/day Zn as Zn sulfate or placebo from 12 to 16 weeks of gestation till delivery. Pregnancy outcome was assessed in term of incidence of intrauterine growth retardation (IUGR), birth weight, crown-heel length, head circumference, Apgar score, and gestational age at delivery. Results. The mean birth head circumference was higher in Zn supplemented group than in the placebo group (35.0cm vs.33.7cm, P<0.05). Although gestational age at delivery (37.1 week vs.36.7 week) and birth weight (2960.6g vs. 2819.0g) of babies born in Zn supplemented group was slightly higher than placebo group, it was not statistically significant. No significant differences were seen for infant length, Apgar score, and IUGR. Conclusions. Adding Zn supplementation during pregnancy to routine care of women with a previous preterm delivery had no significant effect on the gestational age at delivery and birth weight but increased the birth head circumference. © 2010 Informa UK Ltd.