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Gene Expression Analysis of Colon High-Grade Dysplasia Revealed New Molecular Mechanism of Disease



Malekpour H1 ; Heidari MH2 ; Vafaee R3 ; Farshi HM4 ; Khodadoostan M5
Authors
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Authors Affiliations
  1. 1. Gastroenterology, Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gastroenterology and Hepatology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2018

Abstract

Aim: The aim of this research was to find a clear molecular view of dysplasia via network analysis. Background: There are some evidence suggest the relationship between dysplasia and colorectal cancer. Understanding of high-grade dysplasia (HGD) could be beneficial for colon cancer management. Methods: Bioinformatics study of HGD versus healthy subjects was conducted to check the status of differentially expressed genes (DEGs). GSE31106, GPL1261, GSM770092-94 and GSM770101-6 were the sources from gene expression omnibus (GEO) that queried for protein-protein interaction (PPI) network analysis via Cytoscape and its algorithms. Hubs of network were enriched for biochemical pathways and were validated via clustering analysis. Results: Numbers of 46 hub nodes were determined and were included in 12 pathways. A main cluster including 76 nodes was identified containing 45 hubs. 33 hubs among 46 genes were involved in biochemical pathways. IL1B, IL6, TNF, and TRL4 were the most important critical genes. Conclusion: Many different genes as hub nodes might influence the trigger and development of advance condition and also colon cancer. © 2018 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
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