Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Toxicology of Nanobiomaterials Publisher



Bonakdar S1 ; Mashinchian O2
Authors
Show Affiliations
Authors Affiliations
  1. 1. National Cell Bank, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Stem Cell Nanoengineering Published:2015


Abstract

Research on nanostructures continues to evolve with the growth of nanotechnology for diagnostic and therapeutic clinical applications. It is imperative to determine the safety and efficacy of a nanobiomaterial for any specified application. Due to the diverse properties of nanostructures and many unrecognized factors in biological environments, selection of appropriate experiments for determination of injurious effects on biological systems must be precisely performed and interpreted. Although various techniques have been proposed for toxicity evaluation of nanomaterials, to date no single assessment is sufficient. Toxicity observation is initiated by the observation of the cell's response to a nanomaterial which has been preceded by studies in animal models for genotoxicity, immunotoxicity, carcinogenicity or hemolysis. In this text, common methods for evaluation of nanomaterial toxicity are introduced and briefly described. © 2015 Wiley-Blackwell. All rights reserved.
Related Docs
View other Related Docs
1. Necrotic, Apoptotic and Autophagic Cell Fates Triggered by Nanoparticles, Autophagy (2019)
2. Nanotoxicology: Advances and Pitfalls in Research Methodology, Nanomedicine (2015)
3. The Use of Nanoparticles As a Promising Therapeutic Approach in Cancer Immunotherapy, Artificial Cells# Nanomedicine and Biotechnology (2016)
4. Toxicity of Nanoparticles and an Overview of Current Experimental Models, Iranian Biomedical Journal (2016)
5. Biocompatibility and Nanostructured Materials: Applications in Nanomedicine, Artificial Cells# Nanomedicine and Biotechnology (2017)
6. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
7. Clinical Applications of Nanomedicine in Cancer Therapy, Drug Discovery Today (2020)
8. Ros-Mediated Heme Degradation and Cytotoxicity Induced by Iron Nanoparticles: Hemoglobin and Lymphocyte Cells As Targets, Journal of Biomolecular Structure and Dynamics (2018)
Experts (# of related papers)
View all Related Experts
Massoud Amanlou (3)
Mehdi Khoobi (3)
Other Related Docs
9. The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer, Scientific Reports (2018)
10. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)
11. Does Pharmacodynamics of Drugs Change After Presenting Them As Na-Noparticles Like Their Pharmacokinetics?, Current Drug Targets (2020)
12. Acute Toxicity Evaluation of Glycosylated Gd3+-Based Silica Nanoprobe, Molecular Imaging and Biology (2017)
13. Mechanisms of Apoptosis Modulation by Curcumin: Implications for Cancer Therapy, Journal of Cellular Physiology (2019)
14. Study of Silymarin and Vitamin E Protective Effects on Silver Nanoparticle Toxicity on Mice Liver Primary Cell Culture, Acta Medica Iranica (2016)
15. Dose-Response Relationship Study of Selenium Nanoparticles As an Immunostimulatory Agent in Cancer-Bearing Mice, Archives of Medical Research (2015)
16. Melatonin As a Regulator of Apoptosis in Leukaemia: Molecular Mechanism and Therapeutic Perspectives, Frontiers in Pharmacology (2023)
17. Injectable Hydrogel-Based Drug Delivery Systems for Local Cancer Therapy, Drug Discovery Today (2016)
18. Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities, Chemical Reviews (2019)
19. A Comprehensive Insight Into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics, Cancer Investigation (2025)
20. Magneto-Fluorescent Contrast Agents Based on Carbon Dots@Ferrite Nanoparticles for Tumor Imaging, Journal of Magnetism and Magnetic Materials (2022)
21. Magnetic Bio-Metal–Organic Framework Nanocomposites Decorated With Folic Acid Conjugated Chitosan As a Promising Biocompatible Targeted Theranostic System for Cancer Treatment, Materials Science and Engineering C (2019)
22. Application of Nano-Based Systems for Drug Delivery and Targeting: A Review, Journal of Nanoparticle Research (2020)
23. 3D Self-Assembled Nanocarriers for Drug Delivery, Drug Metabolism Reviews (2023)
24. Nanotechnology for Delivery of Gemcitabine to Treat Pancreatic Cancer, Biomedicine and Pharmacotherapy (2017)
25. Toxicity Prediction of Nanoparticles Using Machine Learning Approaches, Toxicology (2024)
26. Application of Nano-Radiosensitizers in Combination Cancer Therapy, Bioengineering and Translational Medicine (2023)
27. Thermal Stress and Tio2 Nanoparticle–Induced Oxidative Dna Damage and Apoptosis in Mouse Hippocampus, Environmental Science and Pollution Research (2022)
28. In Vitro and In Vivo Characteristics of Doxorubicin-Loaded Cyclodextrine-Based Polyester Modified Gadolinium Oxide Nanoparticles: A Versatile Targeted Theranostic System for Tumour Chemotherapy and Molecular Resonance Imaging, Journal of Drug Targeting (2020)
29. Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management, Journal of Psychiatric Research (2024)
30. Unravelling Toxoplasma Treatment: Conventional Drugs Toward Nanomedicine, World Journal of Microbiology and Biotechnology (2021)
31. Electrospun-Based Systems in Cancer Therapy, Electrospun Materials for Tissue Engineering and Biomedical Applications: Research# Design and Commercialization (2017)
32. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
33. Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart internal stimulus-responsive nanocarriers for drug and gene delivery (2015)
34. Potential Toxic Effects of Zirconia Oxide Nanoparticles on Liver and Kidney Factors, Biomedical Research (India) (2015)
35. Reproductive Toxicity of Manganese Dioxide in Forms of Micro-And Nanoparticles in Male Rats, International Journal of Reproductive BioMedicine (2019)
36. Metal Nanoparticles in Atherosclerosis: Applications and Potential Toxicity, Nano Biomedicine and Engineering (2015)
37. Mesoporous Silica Nanoparticles Functionalized With Folic Acid/Methionine for Active Targeted Delivery of Docetaxel, OncoTargets and Therapy (2016)
38. Tumor-Associated Macrophages, Nanomedicine and Imaging: The Axis of Success in the Future of Cancer Immunotherapy, Immunotherapy (2017)
39. Bioavailability, Biodistribution, and Toxicity of Fluorescent Metal Nanoclusters, Luminescent Metal Nanoclusters: Synthesis# Characterization# and Applications (2022)
40. Recent Advances in Porphyrin-Based Nanocomposites for Effective Targeted Imaging and Therapy, Biomaterials (2020)
41. Codelivery of Stat3 Sirna and Bv6 by Carboxymethyl Dextran Trimethyl Chitosan Nanoparticles Suppresses Cancer Cell Progression, International Journal of Pharmaceutics (2020)
42. Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity, Nanomaterials (2018)
43. Effects of Silver Nanoparticles on Human Health, European Journal of Nanomedicine (2015)
44. An Update on Nanoparticle-Based Contrast Agents in Medical Imaging, Artificial Cells# Nanomedicine and Biotechnology (2018)
45. Efficacy of the Hatching Event in Assessing the Embryo Toxicity of the Nano-Sized Tio2 Particles in Zebrafish: A Comparison Between Two Different Classes of Hatching-Derived Variables, Ecotoxicology and Environmental Safety (2015)
46. Modulation of Apoptosis by Melatonin for Improving Cancer Treatment Efficiency: An Updated Review, Life Sciences (2019)
47. Nanoparticles and Targeted Drug Delivery in Cancer Therapy, Immunology Letters (2017)
48. Targeted Delivery of Doxorubicin Into Tumor Cells by Nanostructured Lipid Carriers Conjugated to Anti-Egfrviii Monoclonal Antibody, Artificial Cells# Nanomedicine and Biotechnology (2018)