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Elevated Serum Levels of Adropin in Patients With Type 2 Diabetes Mellitus and Its Association With Insulin Resistance Publisher



Hosseini A1 ; Shanaki M2 ; Emamgholipour S1 ; Nakhjavani M3 ; Razi F4 ; Golmohammadi T1
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Laboratory Medical Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Biology and Today's World Published:2016


Abstract

Evidence suggests a hormone peptide named adropin, is involved in lipid metabolism, insulin resistance, and obesity. However, its role in pathogenesis of type 2 diabetes mellitus (T2DM) is still unclear in humans. Therefore, we investigated whether adropin levels are altered in T2DM patients, and evaluated its association with diabetes- related parameters. Men with T2DM (n=40) and age-matched healthy men (n=40) were participated in case-control study. Serum adropin levels were determined by ELISA. Adropin levels were found to be significantly (p=0.004) higher in T2DM patients (median=2.5ng/ml; interquartile range=1.28ng/ml) compared to healthy controls (Median=1.9ng/ml; interquartile range =0.6ng/ml). Adropin was inversely correlated with FBG (Spearman's rho= -0.335; p=0.017) in T2DM patients and was also negatively correlated with HOMA-IR (Spearman's rho= -0.391; p=0.024). Adropin ≥ 2.25 ng/ml was the best cut-off point to differentiate T2DM patients from healthy controls (sensitivity= 57.5%; specificity= 82.5%; positive predictive value=76.67%; negative predictive value=66%). We showed that T2DM patients have higher adropin levels, and serum level of adropin is inversely associated with insulin resistance; therefore indicating a close association between adropin and T2DM. However, further studies are necessary to establish the role of adropin in diabetes. i¿½ 2016 Ahmad Hosseini et al.
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