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Potential Roles of Adropin in Central Nervous System: Review of Current Literature Publisher



Shahjouei S1 ; Ansari S2 ; Pourmotabbed T3 ; Zand R2, 4
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, United States
  3. 3. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States
  4. 4. Biocomplexity Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States

Source: Frontiers in Molecular Biosciences Published:2016


Abstract

Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed. © 2016 Shahjouei, Ansari, Pourmotabbed and Zand.