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Multicomponent Reaction of Amine, Carbon Disulfide, and Fluoronitrobenzene Via Nucleophilic Attack on the Fluorinated Carbon for the Synthesis of Nitrophenyl Methylcarbamodithioates Publisher



Bahadorikhalili S1 ; Mohammadi S2 ; Asadi M2 ; Barazandeh M2 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. Institute of Mechanics, Iranian Space Research Center, Shiraz, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Chinese Chemical Society Published:2020


Abstract

In this paper, multicomponent reaction of amine, carbon disulfide and fluoronitrobenzene is reported for the synthesis of nitrophenyl methylcarbamodithioate derivatives. The method is based on the nucleophilic attack of the activated methylcarbamodithioate salt to fluoronitrobenzene. Several starting materials are tested and successfully produced the corresponding nitrophenyl methylcarbamodithioate. A possible mechanism for the reaction is suggested. © 2019 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim