Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions

Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions Publisher

Bahadorikhalili S¹ ; Rahimzadeh G² ; Kianmehr E² ; Ansari S³ ; Hamedifar H³ ; Mahdavi M⁴

Show Affiliations

1. Institute of Mechanics, Iranian Space Research Center, Shiraz, Iran
2. School of Chemistry, College of Science, University of Tehran, P. O. Box:14155-6455, Tehran, Iran
3. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: ChemistrySelect Published:2019

Abstract

In this paper, a novel method is introduced for the synthesis of 3-substituted 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives. This methodology is based on the multicomponent one-pot reaction of isatoic anhydride, amines, chloroform and sulfur in basic conditions. The products are obtained in highest efficiency when the reaction is performed in 1,4-dioxane as the solvent in the presence of potassium tert-butoxide as the base. The reaction showes to be efficient and simple for the preparation of these compounds. In addition, this method is general and different aromatic or aliphatic amines are used and the desired products are isolated in high yields. A possible mechanism for the reaction is proposed, which consisted the dichlorocarbene formation under the basic conditions. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Style	Citing Format
MLA	Bahadorikhalili S, et al.. "Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions." ChemistrySelect, vol. 4, no. 1, 2019, pp. 100-104.
APA	Bahadorikhalili S, Rahimzadeh G, Kianmehr E, Ansari S, Hamedifar H, Mahdavi M (2019). Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions. ChemistrySelect, 4(1), 100-104.
Chicago	Bahadorikhalili S, Rahimzadeh G, Kianmehr E, Ansari S, Hamedifar H, Mahdavi M. "Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions." ChemistrySelect 4, no. 1 (2019): 100-104.
Harvard	Bahadorikhalili S et al. (2019) 'Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions', ChemistrySelect, 4(1), pp. 100-104.
Vancouver	Bahadorikhalili S, Rahimzadeh G, Kianmehr E, Ansari S, Hamedifar H, Mahdavi M. Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions. ChemistrySelect. 2019;4(1):100-104.
BibTex	@article{ author = {Bahadorikhalili S and Rahimzadeh G and Kianmehr E and Ansari S and Hamedifar H and Mahdavi M}, title = {Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions}, journal = {ChemistrySelect}, volume = {4}, number = {1}, pages = {100-104}, year = {2019} }
RIS	TY - JOUR AU - Bahadorikhalili S AU - Rahimzadeh G AU - Kianmehr E AU - Ansari S AU - Hamedifar H AU - Mahdavi M TI - Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions JO - ChemistrySelect VL - 4 IS - 1 SP - 100 EP - 104 PY - 2019 ER -

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