Caffeine and Mitochondria With a Focus on the Central Nervous System Publisher



Momtaz S^{1, 2} ; Hassani S² ; Maghsoudi AS² ; Abdolghaffari AH¹ ; Abdollahi M²
Source: Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health Published:2021

Abstract

Mitochondria are central pieces of machinery of energy production within the cells. Mitochondrial deficits may be functional and structural or a result from aberrations in mitochondrial DNA (mtDNA), which is associated with several metabolic and chronic impairments. Improvement of mitochondrial function may be achieved by a verity of natural and chemical agents. Thereby, pathways or agents that regulate mitochondrial function are therapeutic targets for these diseases. Caffeine was shown to induce mitochondrial function and biogenesis. Depending on caffeine concentration and the target organ, this compound plays both inhibitory and stimulating roles on mitochondrial function. Here, we present a brief introduction to caffeine and its pharmacological activities. Besides, the involvement of mitochondria in some physiological actions at the presence of caffeine is discussed, with specific emphasis on caffeine effects on neurodegenerative diseases. © 2021 Elsevier Inc. All rights reserved.