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The Usefulness of Cardiopulmonary Exercise Testing in Assessment of Patients With Suspected Coronary Artery Disease Publisher Pubmed



Mazaheri R1, 2 ; Shakerian F3 ; Vasheghanifarahani A4 ; Halabchi F1, 2 ; Mirshahi M1, 5 ; Mansournia MA6
Authors
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Authors Affiliations
  1. 1. Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Medicine, Department of Sports and Exercise Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology & Biostatistics, Tehran University of Medical Sciences, Tehran, Iran

Source: Postgraduate Medical Journal Published:2016


Abstract

Objective The aim of this study is to assess different parameters of cardiopulmonary exercise testing that can predict the development of myocardial ischaemia in patients with suspected coronary artery disease (CAD) and to identify the parameters which have more correlation with myocardial ischaemia. Study design Cross-sectional study. Methods In this study, a total of 31 men (mean age 57.23±11.09 years) with suggestive symptoms of CAD underwent an exercise stress test with breath-by-breath gas exchange analysis, followed by coronary angiography as the gold standard for diagnosing CAD. Results The ventilation versus CO2 output (VE/VCO2) peak was significantly different between patients with negative and positive angiography results. Receiver operator characteristic analysis showed an area under the curve of 0.73 for VE/VCO2 peak with diagnostic threshold equal to 35 (95% CI 0.54 to 0.9; p=0.05). Exercise stress testing had sensitivity and specificity of 75% and 40%, respectively. Conclusions A change in ventilatory efficiency assessed using the VE/VCO2 peak has the predictive ability to identify exercise-induced myocardial ischaemia. The present study has provided additional evidence of the potential clinical value of cardiopulmonary exercise testing in the diagnosis of CAD. © 2016, BMJ Publishing Group. All rights reserved.