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Increased Mitochondrial Dna Copy Number and Oxidative Damage in Patients With Hashimoto’S Thyroiditis



Esfahanian F1 ; Hazaveh MM2 ; Garehbagh LH1 ; Falahati K3 ; Ataei M3 ; Sanati MH3 ; Jadali Z4
Authors
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Authors Affiliations
  1. 1. Department of Endocrinology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  4. 4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2021

Abstract

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the patho-physiology of HT. © 2021 Esfahanian et al. Published by Tehran University of Medical Sciences.
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